(5E)-5-[[5-(3-nitrophenyl)furan-2-yl]methylidene]-1,3-thiazolidine-2,4-dione

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (5E)-5-[[5-(3-nitrophenyl)furan-2-yl]methylidene]-1,3-thiazolidine-2,4-dione
• 化学式: C14H8N2O5S
• 分子量: 316.29
• InChiKey: JVYYPXLIZVPGAD-KPKJPENVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  130
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Methods of modulating neurotrophin-mediated activity
  申请人：Ross M. Gregory

  公开号：US20050282840A1

  公开（公告）日：2005-12-22

  Disclosed are compositions which modulate the interaction of nerve growth factor and brain-derived neurotrophic factor with neurotrophic receptors. Also disclosed are methods of using the compositions of the invention, including methods of administration.

  本发明揭示了一种调节神经生长因子和脑源性神经营养因子与神经营养受体相互作用的组合物。还揭示了使用该发明的组合物的方法，包括给药方法。
• COMPOSITIONS AND METHODS FOR TREATMENT OF DISEASE CAUSED BY YERSINIA SPP INFECTION
  申请人：Mustelin Tomas Mikael

  公开号：US20090312352A1

  公开（公告）日：2009-12-17

  The invention generally relates to compositions and methods for treatment of disease caused by Yersinia spp. infection. More specifically, the invention relates to protein tyrosine phosphatase inhibitors and derivatives and analogs thereof, pharmaceutical compositions containing the protein tyrosine phosphatase inhibitors and analogs, methods of making the protein tyrosine phosphatase inhibitors and analogs and methods of use thereof.

  本发明通常涉及用于治疗由耶尔森氏菌感染引起的疾病的组合物和方法。更具体地，本发明涉及蛋白酪氨酸磷酸酶抑制剂及其衍生物和类似物，含有蛋白酪氨酸磷酸酶抑制剂和类似物的制药组合物，制造蛋白酪氨酸磷酸酶抑制剂和类似物的方法以及使用它们的方法。
• EP1718308A4
  申请人：——

  公开号：EP1718308A4

  公开（公告）日：2007-07-18
• METHODS OF MODULATING NEUROTROPHIN-MEDIATED ACTIVITY
  申请人：PainCeptor Pharma Corp.

  公开号：EP1718308A2

  公开（公告）日：2006-11-08
• [EN] METHODS OF MODULATING NEUROTROPHIN-MEDIATED ACTIVITY<br/>[FR] PROCÉDÉ DE MODULATION DE L'ACTIVITÉ PROVOQUÉE PAR L'INTERMÉDIAIRE DE LA NEUROTROPHINE
  申请人：PAINCEPTOR PHARMA CORP

  公开号：WO2005076695A2

  公开（公告）日：2005-08-25

  Disclosed are compositions which modulate the interaction of nerve growth factor and brain-derived neurotrophic factor with neurotrophic receptors, comprising contacting cells expressing a neurotrophin receptor with an effective amount of a compound of Formulas 1-6. Also disclosed are methods of using the compositions of the invention for the treatment of pain, inflammatory disorder and neurological disorder in subject in need.