N-(4-methylphenyl)-2-pyridin-1-ium-1-ylacetamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(4-methylphenyl)-2-pyridin-1-ium-1-ylacetamide
• 化学式: C14H15N2O+
• 分子量: 227.28
• InChiKey: OTSZXAQEBMPJAL-UHFFFAOYSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  33
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• Ceramides and Apoptosis-Signaling Ligand
  申请人：Bielawska Alicja

  公开号：US20080045470A1

  公开（公告）日：2008-02-21

  The invention provides the compounds of formula ( ): and pharmaceutically acceptable salts thereof, wherein R 1 , R 2 , R 3 , R 4 , A, X, Y, a, b and n are as defined herein. Also disclosed are methods for making the compounds of formula (I) and their use in treating or preventing diseases associated with cell overproliferation and dysfunctional sphingolipid signal transduction. The invention also encompasses the use of the compounds in combination with an apoptosis-signaling ligand, such as Fas ligand. Preferably, the Fas ligand is administered in the form of a gene therapy agent.