N-[[4-[4-(thiophene-2-carbonyl)piperazin-1-yl]phenyl]carbamothioyl]thiophene-2-carboxamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[[4-[4-(thiophene-2-carbonyl)piperazin-1-yl]phenyl]carbamothioyl]thiophene-2-carboxamide
• 化学式: C₂₁H₂₀N₄O₂S₃
• 分子量: 456.6
• InChiKey: PFCNPKGDFIEVPH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  30
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  153
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Method for testing and screening p38 map kinase modifiers
  申请人：THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

  公开号：US10738345B2

  公开（公告）日：2020-08-11

  This invention provides methods for treating diseases associated with elevated p38 mitogen-activated protein kinase activity. Moreover, the invention provides methods for testing a candidate compound for a p38 mitogen-activated protein kinase modifying activity by calculating the level of relocalization of an SMN complex component from the cytoplasm to the nucleus of a cell. Additionally, the invention provides a kit and a system for calculating the same.

  本发明提供了治疗与 p38 丝裂原活化蛋白激酶活性升高有关的疾病的方法。此外，本发明还提供了通过计算 SMN 复合物组分从细胞质到细胞核的再定位水平来检测 p38 丝裂原活化蛋白激酶修饰活性候选化合物的方法。此外，本发明还提供了用于计算相同结果的试剂盒和系统。
• METHOD FOR TESTING AND SCREENING P38 MAP KINASE MODIFIERS
  申请人：Dreyfuss Gideon

  公开号：US20100297665A1

  公开（公告）日：2010-11-25

  This invention provides methods for treating diseases associated with elevated p38 mitogen-activated protein kinase activity. Moreover, the invention provides methods for testing a candidate compound for a p38 mitogen-activated protein kinase modifying activity by calculating the level of relocalization of an SMN complex component from the cytoplasm to the nucleus of a cell. Additionally, the invention provides a kit and a system for calculating the same.
• US9926588B2
  申请人：——

  公开号：US9926588B2

  公开（公告）日：2018-03-27
• [EN] A METHOD FOR TESTING AND SCREENING P38 MAP KINASE MODIFIERS<br/>[FR] PROCÉDÉ DESTINÉ À TESTER ET CRIBLER DES ÉLÉMENTS MODIFIANT LA P38 MAP KINASE
  申请人：UNIV PENNSYLVANIA

  公开号：WO2008150516A1

  公开（公告）日：2008-12-11

  [EN] This invention provides methods for treating diseases associated with elevated p38 mitogen- activated protein kinase activity. Moreover, the invention provides methods for testing a candidate compound for a p38 mitogen-activated protein kinase modifying activity by calculating the level of relocalization of an SMN complex component from the cytoplasm to the nucleus of a cell. Additionally, the invention provides a kit and a system for calculating the same.
  [FR] La présente invention concerne des procédés permettant de traiter des maladies associées à une activité accrue d'une protéine kinase activée par le mitogène p38. De plus, l'invention porte sur des procédés permettant de tester un composé candidat pour une activité modifiant une protéine kinase activée par le mitogène p38 grâce au calcul du niveau de relocalisation d'un composant du complexe SMN du cytoplasme vers le noyau d'une cellule. En outre, l'invention a trait à un kit et un système permettant de calculer la relocalisation.