patulolide A | 109718-21-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酯类和类似物
• 英文名称: patulolide A
• 英文别名: (3E)-12-Methyl-oxacyclododec-3-ene-2,5-dione；(3E)-12-methyl-1-oxacyclododec-3-ene-2,5-dione
• CAS: 109718-21-0
• 化学式: C₁₂H₁₈O₃
• 分子量: 210.273
• InChiKey: XETYGXGLGYXEIT-CMDGGOBGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  patulolide A 在 碘 作用下， 生成 patulolide B
  参考文献：
  名称：

  A New Approach to Macrocyclization via Alkene Formation in Catalytic Diazo Decomposition. Synthesis of Patulolides A and B

  摘要：

  [GRAPHICS]Effective synthetic uses of bisdiazocarbonyl compounds for the selective construction of diverse macrocycles, including the synthesis of patulolides A and a, by catalytic "carbene dimer" formation are reported. Control of stereochemistry and efficient methods for product isomerization or kinetic isomer differentiation have been achieved.

  DOI：

  10.1021/ol005983j
• 作为产物：
  描述：

  (E)-10-Methyl-1,4,9-trioxa-spiro[4.11]hexadec-6-en-8-one 生成 patulolide A
  参考文献：
  名称：

  AYYARGAR, N. R.;CHANDA, B.;WAKHARKAR, R. D.;KASAR, R. A., SYNTH. COMMUN., 18,(1988) N 16-17, C. 2103-2109

  摘要：

  DOI：

文献信息

• AYYARGAR, N. R.;CHANDA, B.;WAKHARKAR, R. D.;KASAR, R. A., SYNTH. COMMUN., 18,(1988) N 16-17, C. 2103-2109
  作者：AYYARGAR, N. R.、CHANDA, B.、WAKHARKAR, R. D.、KASAR, R. A.

  DOI：——

  日期：——
• A New Approach to Macrocyclization via Alkene Formation in Catalytic Diazo Decomposition. Synthesis of Patulolides A and B
  作者：Michael P. Doyle、Wenhao Hu、Iain M. Phillips、Andrew G. H. Wee

  DOI：10.1021/ol005983j

  日期：2000.6.1

  [GRAPHICS]Effective synthetic uses of bisdiazocarbonyl compounds for the selective construction of diverse macrocycles, including the synthesis of patulolides A and a, by catalytic "carbene dimer" formation are reported. Control of stereochemistry and efficient methods for product isomerization or kinetic isomer differentiation have been achieved.