4-chloro-N-(4-morpholinobenzyl)aniline | 1039998-34-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-chloro-N-(4-morpholinobenzyl)aniline
• 英文别名: 4-chloro-N-[(4-morpholin-4-ylphenyl)methyl]aniline
• CAS: 1039998-34-9
• 化学式: C₁₇H₁₉ClN₂O
• 分子量: 302.804
• InChiKey: DRAOASBQZCYWQU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  24.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-(4-吗啉基)苄醇 、 对氯苯胺 在 indium(III) triflate 作用下， 以 水 为溶剂， 反应 6.0h， 以76%的产率得到4-chloro-N-(4-morpholinobenzyl)aniline
  参考文献：
  名称：

  In(OTf)3 catalyzed N-benzylation of amines utilizing benzyl alcohols in water

  摘要：

  An In(OTf)(3)-catalyzed N-benzylation of amines utilizing benzyl alcohols through direct C-O bond activation has been reported. The reaction was performed in water without any base, additive, ligand or inert gas protection to afford the chem-selective mono- or bis-alkylated aromatic amines in good to excellent yields. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2013.07.010

文献信息

• In(OTf)3 catalyzed N-benzylation of amines utilizing benzyl alcohols in water
  作者：Jin-Ming Yang、Ran Jiang、Lin Wu、Xiao-Ping Xu、Shun-Yi Wang、Shun-Jun Ji

  DOI：10.1016/j.tet.2013.07.010

  日期：2013.9

  An In(OTf)(3)-catalyzed N-benzylation of amines utilizing benzyl alcohols through direct C-O bond activation has been reported. The reaction was performed in water without any base, additive, ligand or inert gas protection to afford the chem-selective mono- or bis-alkylated aromatic amines in good to excellent yields. (C) 2013 Elsevier Ltd. All rights reserved.