5-{[5-(3-chloro-4-methoxyphenyl)-2-furyl]methylene}-1,3-diphenyl-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-{[5-(3-chloro-4-methoxyphenyl)-2-furyl]methylene}-1,3-diphenyl-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione
• 英文别名: 5-[[5-(3-chloro-4-methoxyphenyl)furan-2-yl]methylidene]-1,3-diphenyl-2-sulfanylidene-1,3-diazinane-4,6-dione
• 化学式: C₂₈H₁₉ClN₂O₄S
• mdl: MFCD00609483
• 分子量: 515.0
• InChiKey: PCWLJXOJHZAIRA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  36
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  95.1
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• Method and compounds for inhibition of cell death
  申请人：——

  公开号：US20040171629A1

  公开（公告）日：2004-09-02

  The invention is directed to methods and compositions for inhibiting caspase-independent apoptosis. In particular, methods and compositions for inhibiting Omi/HtrA2 activity, as well as method for identifying other inhibitors of Omi/HtrA2. Also disclosed are Omi/HtrA2 specific substrates and methods for identifying other substrates of Omi/HtrA2.

  本发明涉及抑制不依赖于 Caspase 的细胞凋亡的方法和组合物。特别是抑制 Omi/HtrA2 活性的方法和组合物，以及鉴定 Omi/HtrA2 其他抑制剂的方法。还公开了 Omi/HtrA2 特异性底物和鉴定 Omi/HtrA2 其他底物的方法。
• METHOD AND COMPOUNDS FOR INHIBITION OF CELL DEATH
  申请人：Zervos Antonis

  公开号：US20100311772A1

  公开（公告）日：2010-12-09

  The invention is directed to methods and compositions for inhibiting caspase-independent apoptosis. In particular, methods and compositions for inhibiting Omi/HtrA2 activity, as well as method for identifying other inhibitors of Omi/HtrA2. Also disclosed are Omi/HtrA2 specific substrates and methods for identifying other substrates of Omi/HtrA2.
• US7713981B2
  申请人：——

  公开号：US7713981B2

  公开（公告）日：2010-05-11
• US8242122B2
  申请人：——

  公开号：US8242122B2

  公开（公告）日：2012-08-14