6-azidopyridine-3-carboxylic acid | 351324-62-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 6-azidopyridine-3-carboxylic acid
• 英文别名: 6-azido-nicotinic acid
• CAS: 351324-62-4
• 化学式: C₆H₄N₄O₂
• 分子量: 164.123
• InChiKey: BIHYXYPOWIPXKO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  64.6
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  6-azidopyridine-3-carboxylic acid 以 三氟乙酸 为溶剂， 生成 四唑并[1,5-a]吡啶-6-羧酸
  参考文献：
  名称：

  Cmoch, Piotr; Stefaniak, Lech; Webb, Graham A., Magnetic Resonance in Chemistry, 1997, vol. 35, # 4, p. 237 - 242

  摘要：

  DOI：
• 作为产物：
  描述：

  6-氯烟酸 在 sodium azide 作用下， 以 乙醇 、 水 为溶剂， 生成 6-azidopyridine-3-carboxylic acid
  参考文献：
  名称：

  Tuning activation and self-immolative properties of the bioorthogonal alkene–azide click-and-release strategy

  摘要：

  芳基叠氮化物和反式环辛烯的组合已在生物正交点击释放策略中进行研究，两种反应配对可以快速释放微摘米浓度的酚。

  DOI：

  10.1039/d0ob00936a

文献信息

• Amide compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use
  申请人：——

  公开号：US20020103203A1

  公开（公告）日：2002-08-01

  Amide compounds that modulate and/or inhibit the activity of certain protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating tyrosine kinase signal transduction in order to modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.

  描述了调节和/或抑制特定蛋白激酶活性的酰胺化合物。这些化合物和含有它们的药物组合物能够介导酪氨酸激酶信号传导，以调节和/或抑制不需要的细胞增殖。该发明还涉及含有这些化合物的药物组合物的治疗或预防用途，以及通过给予这些化合物的有效量来治疗癌症以及与不需要的血管生成和/或细胞增殖相关的其他疾病状态，如糖尿病视网膜病变、新生血管性青光眼、类风湿性关节炎和牛皮癣的方法。
• PROCESS FOR THE ATTACHMENT OF A GALNAC MOIETY COMPRISING A (HETERO)ARYL GROUP TO A GLCNAC MOIETY, AND PRODUCT OBTAINED THEREBY
  申请人：SynAffix B.V.

  公开号：EP3097200A1

  公开（公告）日：2016-11-30
• [EN] PROCESS FOR THE ATTACHMENT OF A GALNAC MOIETY COMPRISING A (HETERO)ARYL GROUP TO A GLCNAC MOIETY, AND PRODUCT OBTAINED THEREBY<br/>[FR] PROCÉDÉ POUR LA FIXATION D'UNE FRACTION GALNAC COMPRENANT UN GROUPE (HÉTÉRO)ARYLE À UNE FRACTION GLCNAC, ET PRODUIT AINSI OBTENU
  申请人：SYNAFFIX BV

  公开号：WO2015112013A1

  公开（公告）日：2015-07-30

  The present invention relates to a process for attaching an N-acetylgalactosamine- (hetero)arylmoiety to an N-acetylglucosaminemoiety, the process comprising the step of contacting the N-acetylgalactosamine-(hetero)arylmoiety with the N- acetylglucosaminemoiety in the presence of a mutant galactosyltransferase, wherein the N-acetylglucosaminemoiety is according to Formula (1)the N- acetylgalactosamine-(hetero)arylmoiety is according to Formula (2): In a particularly preferred embodiment of the process according to the invention, the N-acetylgalactosamine-(hetero)arylmoiety comprises a 1,3-dipole functional group, and the N-acetylglucosaminemoiety is a terminal GlcNAc moiety of a glycoprotein glycan. The invention further relates to a productobtainable by the process according to the invention, in particular to glycoproteins. Also, the invention relates to several compounds comprising an N-acetylgalactosamine-(hetero)arylmoiety.
• Tuning activation and self-immolative properties of the bioorthogonal alkene–azide click-and-release strategy
  作者：Jessica M. Fairhall、Madoka Murayasu、Sumit Dadhwal、Sarah Hook、Allan B. Gamble

  DOI：10.1039/d0ob00936a

  日期：——

  Combinations of aryl azides and trans-cyclooctenes have been studied in a bioorthogonal click-and-release strategy, with two reaction pairings rapidly releasing phenol at micromolar concentrations.

  芳基叠氮化物和反式环辛烯的组合已在生物正交点击释放策略中进行研究，两种反应配对可以快速释放微摘米浓度的酚。
• Cmoch, Piotr; Stefaniak, Lech; Webb, Graham A., Magnetic Resonance in Chemistry, 1997, vol. 35, # 4, p. 237 - 242
  作者：Cmoch, Piotr、Stefaniak, Lech、Webb, Graham A.

  DOI：——

  日期：——