Butyl 2-(acetylamino)benzoate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Butyl 2-(acetylamino)benzoate
• 英文别名: butyl 2-acetamidobenzoate
• 化学式: C₁₃H₁₇NO₃
• 分子量: 235.28
• InChiKey: PLYLRMGCCAJWFI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• A percutaneous absorption promoter, a tape plaster and a method of promoting percutaneous absorption
  申请人：LINTEC Corporation

  公开号：EP0552405A1

  公开（公告）日：1993-07-28

  A percutaneous absorption promoter comprises a derivative of amino acid in which the amino group has or does not have an acyl substituent or a hydrocarbon substituent, the carboxylic group has a hydrocarbon substituent and the part between the amino group and the carboxylic group has a specified structure. A tape plaster comprises the percutaneous absorption promoter described above. The method utilizes the the percutaneous absorption promoter described above. The percutaneous promoter of the invention has excellent ability of promoting the percutaneous absorption of pharmacologically active substances and excellent safety simultaneously, capable of delivering the desired pharmacologically active substances rapidly to the location of treatment or to all parts of the body through the circulating system and effective for curing various kinds of disease. The tape plaster comprising it and the method of promoting percutaneous absorption by utilizing it have the same advantages.

  一种经皮吸收促进剂包括一种氨基酸衍生物，其中的氨基具有或不具有酰基取代基 或烃基取代基，羧基具有烃基取代基，氨基和羧基之间的部分具有特定结构。胶带膏药包含上述经皮吸收促进剂。该方法利用了上述经皮吸收促进剂。 本发明的经皮吸收促进剂具有良好的促进药理活性物质经皮吸收的能力，同时具有极佳的安全性，能够将所需的药理活性物质通过循环系统快速输送到治疗部位或身体各部位，有效治疗各种疾病。由它组成的胶带膏药和利用它促进经皮吸收的方法具有相同的优点。
• A percutaneous absorption, a tape plaster and a method of promoting percutaneous absorption
  申请人：LINTEC Corporation

  公开号：EP0815871A1

  公开（公告）日：1998-01-07

  A percutaneous absorption promoter comprises a derivative of amino acid in which the amino group has or does not have an acyl substituent or a hydrocarbon substituent, the carboxylic group has a hydrocarbon substituent and the part between the amino group and the carboxylic group has a specified structure. A tape plaster comprises the percutaneous absorption promoter described above. The method utilizes the the percutaneous absorption promoter described above. The percutaneous promoter of the invention has excellent ability of promoting the percutaneous absorption of pharmacologically active substances and excellent safety simultaneously, capable of delivering the desired pharmacologically active substances rapidly to the location of treatment or to all parts of the body through the circulating system and effective for curing various kinds of disease. The tape plaster comprising it and the method of promoting percutaneous absorption by utilizing it have the same advantages.

  一种经皮吸收促进剂包括一种氨基酸衍生物，其中的氨基具有或不具有酰基取代基 或烃基取代基，羧基具有烃基取代基，氨基和羧基之间的部分具有特定结构。胶带膏药包含上述经皮吸收促进剂。该方法利用了上述经皮吸收促进剂。 本发明的经皮吸收促进剂具有良好的促进药理活性物质经皮吸收的能力，同时具有极佳的安全性，能够将所需的药理活性物质通过循环系统快速输送到治疗部位或身体各部位，有效治疗各种疾病。由它组成的胶带膏药和利用它促进经皮吸收的方法具有相同的优点。
• Tape plaster comprising anthranilic acid derivatives as percutaneous absorption promotors
  申请人：LINTEC Corporation

  公开号：EP0815871B1

  公开（公告）日：2002-07-17