N-[(4-fluorophenyl)methyl]pentanamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[(4-fluorophenyl)methyl]pentanamide
• 化学式: C₁₂H₁₆FNO
• mdl: MFCD01349971
• 分子量: 209.26
• InChiKey: QMCOCDXDFLCWDP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF VIRAL INFECTIONS
  申请人：Idenix Pharmaceuticals LLC

  公开号：EP2755985B1

  公开（公告）日：2017-11-01
• [EN] COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF VIRAL INFECTIONS<br/>[FR] COMPOSÉS ET COMPOSITIONS PHARMACEUTIQUES POUR LE TRAITEMENT D'INFECTIONS VIRALES
  申请人：IDENIX PHARMACEUTICALS INC

  公开号：WO2013039855A1

  公开（公告）日：2013-03-21

  Provided herein are compounds, compositions and methods for the treatment of liver disorders, including HCV infections. In one embodiment, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents.
• [EN] PYRIDAZINONES FOR THE TREATMENT OF CANCER<br/>[FR] PYRIDAZINONES POUR LE TRAITEMENT DU CANCER
  申请人：MAX PLANCK GES ZUR FÖRDERUNG DER WISSENSCHAFTEN E V

  公开号：WO2015189433A1

  公开（公告）日：2015-12-17

  The present invention relates to novel substituted pyrrolo- and pyrazolo-pyridazinones, as well as pharmaceutical compositions containing at least one of these substituted pyrrolo- and pyrazolo-pyridazinones together with at least one pharmaceutically acceptable carrier, excipient and/or diluent. Said novel substituted pyrrolo- and pyrazolo-pyridazinones are binding to the prenyl binding pocket of PDE5 and therefore, are useful for the prophylaxis and treatment of cancer by inhibition of the binding of PDEδ to farnesylated Ras proteins and thereby, inhibition of oncogenic Ras signaling in cells.