(2S)-2-methyl-3-phenylpropan-1-amine | 89999-55-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2S)-2-methyl-3-phenylpropan-1-amine
• CAS: 89999-55-3
• 化学式: C₁₀H₁₅N
• 分子量: 149.236
• InChiKey: SVBLNCJETIXIPV-VIFPVBQESA-N

物化性质

• 沸点：
  100-110 °C(Press: 15 Torr)
• 密度：
  0.936±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (2S)-2-methyl-3-phenylpropan-1-amine 、 alpha-甲基异氰酸苄酯 生成 1-[(2S)-2-methyl-3-phenylpropyl]-3-(1-phenylethyl)urea
  参考文献：
  名称：

  POTAPOV V. M.; DEMYANOVICH V. M.; SOLOVEVA L. D.; VENDROVA O. E., XIMIYA GETEROTSIKL. SOEDIN. 1981, HO 5, 675-677

  摘要：

  DOI：
• 作为产物：
  描述：

  (2S)-2-(methoxymethyl)-N-[(2S)-2-methyl-3-phenylpropyl]pyrrolidin-1-amine 以52%的产率得到
  参考文献：
  名称：

  ENDERS, D.;SCHUBERT, H., ANGEW. CHEM., 1984, 96, N 5, 368-369

  摘要：

  DOI：

文献信息

• Pyridone derivatives having a binding activity to the cannabinoid type 2 recepter
  申请人：TADA Yukio

  公开号：US20100081686A1

  公开（公告）日：2010-04-01

  It was found that the compound having a binding activity to the cannabinoid type 2 receptor represented by the formula (I): wherein R 1 is a group represented by the formula: —Y 1 —Y 2 —Y 3 —R a wherein Y 1 is single bond or the like; Y 2 is —C(═O)—NH— or the like; Y 3 is optionally substituted aryl or the like; R 2 is hydrogen or the like; R 3 is alkyl or the like; R 4 is alkyl or the like; R 5 is optionally substituted alkyl or the like; or R 3 and R 4 taken together with the adjacent atom form cyclic group or the like.

  发现化合物具有与cannabinoid type 2受体结合活性，该化合物的公式为（I）：其中R1是由公式表示的基团：—Y1—Y2—Y3—Ra，其中Y1是单键或类似物；Y2是—C（═O）—NH—或类似物；Y3是可选择的取代芳基或类似物；R2是氢或类似物；R3是烷基或类似物；R4是烷基或类似物；R5是可选择的取代烷基或类似物；或R3和R4与相邻原子结合形成环状基团或类似物。
• NOVEL NICOTINAMIDE DERIVATIVE OR SALT THEREOF
  申请人：FUJIWARA Hideyasu

  公开号：US20130116430A1

  公开（公告）日：2013-05-09

  An object of the present invention is to provide to a compound and a pharmaceutical composition, which have excellent Syk-inhibitory activity. The present invention provides a nicotinamide derivative represented by the following formula (I) (wherein R 1 represents a halogen atom; R 2 represents a C 1-12 alkyl group, a C 2-12 alkenyl group, a C 2-12 alkynyl group, a C 3-8 cycloalkyl group, an aryl group, an ar-C 1-6 alkyl group or a heterocyclic group, each optionally having at least one substituent; R 3 represents an aryl group or a heterocyclic group each optionally having at least one substituent; and R 4 and R 5 each independently represent a hydrogen atom; and R 2 and R 4 may form a cyclic amino group optionally having at least one substituent together with the nitrogen atom to which they bind) or a salt thereof, and a pharmaceutical composition for use in the treatment of a Syk-related disease which comprises the nicotinamide derivative or a salt thereof.

  本发明的目的是提供一种具有优异的Syk抑制活性的化合物和制药组合物。本发明提供了一种由以下式(I)表示的烟酰胺衍生物（其中R1表示卤素原子；R2表示C1-12烷基、C2-12烯基、C2-12炔基、C3-8环烷基、芳基、芳基-C1-6烷基或杂环基，每种均可选地具有至少一个取代基；R3表示芳基或杂环基，每种均可选地具有至少一个取代基；R4和R5各自独立地表示氢原子；且R2和R4可以与它们结合的氮原子一起形成具有至少一个取代基的环状氨基团）或其盐，并且用于治疗Syk相关疾病的制药组合物包括该烟酰胺衍生物或其盐。
• Antipruritics
  申请人：SHIONOGI & CO., LTD.

  公开号：EP2130820A1

  公开（公告）日：2009-12-09

  The present invention relates to the use of a compound having an agonistic activity to the cannabinoid receptor, a prodrug, a pharmaceutically acceptable salt or solvate thereof for the preparation of an antipruritic, wherein the compound having an agonistic activity to the cannabinoid receptor is a compound selected from (R,S)-4,4,4-trifluoro-1-butane sulfonic acid-3-(2-hydroxymethyl-indanyl-4-oxy)-phenylester; (S)-1-(4,4,4-trifluoro-1-butane sulfonic acid-3-(2-hydroxymethyl-indanyl-4-oxy)phenyl ester; and (R)-1-(4,4,4-trifluoro-1-butane sulfonic acid-3-(2-hydroxymethyl-indanyl-4-oxy)phenyl ester.

  本发明涉及一种对大麻素受体具有激动活性的化合物、其原药、药学上可接受的盐或溶液用于制备止痒剂的用途，其中对大麻素受体具有激动活性的化合物是选自以下各项的化合物 (R,S)-4,4,4-三氟-1-丁烷磺酸-3-(2-羟甲基-茚满-4-氧基)-苯酯； (S)-1-(4,4,4-三氟-1-丁烷磺酸-3-(2-羟甲基-茚满-4-氧基)苯基酯；和 (R)-1-(4,4,4-三氟-1-丁烷磺酸-3-(2-羟甲基-茚满-4-氧基)苯基酯。
• ANTIPRURITICS
  申请人：SHIONOGI & CO., LTD.

  公开号：EP1477186B1

  公开（公告）日：2009-11-11
• 2-PYRIDONE DERIVATIVES HAVING AFFINITY FOR CANNABINOID TYPE 2 RECEPTOR
  申请人：SHIONOGI & CO., LTD.

  公开号：EP1357111B1

  公开（公告）日：2009-08-05