2-nitro-4-((6-nitroquinolin-4-yl)amino)-N-(4-(pyridin-4-ylamino)phenyl)benzamide | 53221-75-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-nitro-4-((6-nitroquinolin-4-yl)amino)-N-(4-(pyridin-4-ylamino)phenyl)benzamide
• 英文别名: Benzamide, 2-nitro-4-((6-nitro-4-quinolinyl)amino)-N-(4-(4-pyridinylamino)phenyl)-；2-nitro-4-[(6-nitroquinolin-4-yl)amino]-N-[4-(pyridin-4-ylamino)phenyl]benzamide
• CAS: 53221-75-3
• 化学式: C₂₇H₁₉N₇O₅
• 分子量: 521.492
• InChiKey: YUOOWNPVFAMPNZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  39
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  171
• 氢给体数：
  3
• 氢受体数：
  9

文献信息

• COMPOSITIONS FOR MODULATING PD-1 SIGNAL TRANSDUCTION
  申请人：Augusta University Research Institute, Inc.

  公开号：EP3548022A1

  公开（公告）日：2019-10-09
• [EN] COMPOSITIONS FOR MODULATING PD-1 SIGNAL TRANSDUCTION<br/>[FR] COMPOSITIONS POUR MODULER LA TRANSDUCTION DU SIGNAL PD-1
  申请人：UNIV RES INST INC AUGUSTA

  公开号：WO2018100556A1

  公开（公告）日：2018-06-07

  Several compounds have been discovered that modulate signal transduction through the PD-1 receptor. In certain embodiments, the compounds promote or induce an activating signal through the PD-1 receptor that activates a T cell. The compounds can bind to PD-1 and inhibit or prevent ligands from binding to PD-1 and thereby suppress inhibitory signal transduction through the PD-1 receptor.