Ethyl 4-[(3-hydroxy-3,5-dimethylhex-5-enoxy)carbonylamino]benzoate | 457898-93-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Ethyl 4-[(3-hydroxy-3,5-dimethylhex-5-enoxy)carbonylamino]benzoate
• 英文别名: ethyl 4-[(3-hydroxy-3,5-dimethylhex-5-enoxy)carbonylamino]benzoate
• CAS: 457898-93-0
• 化学式: C₁₈H₂₅NO₅
• 分子量: 335.4
• InChiKey: FPHQPVJLTVJSHE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  24
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  84.9
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  Ethyl 4-[(3-hydroxy-3,5-dimethylhex-5-enoxy)carbonylamino]benzoate 在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 以75%的产率得到4-[(3-Hydroxy-3,5-dimethylhex-5-enoxy)carbonylamino]benzoic acid
  参考文献：
  名称：

  Development of a genetic selection for catalytic antibodies

  摘要：

  The design and evaluation of a new genetic selection system for evolving catalytic antibodies with aldolase activity are described. Through a series of model selections, we have identified selection conditions where expression of a catalytically active antibody confers a growth advantage to Escherichia coli. In addition, we provide evidence that the growth advantage is a direct result of catalytic activity. (C) 2002 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(02)00198-1
• 作为产物：
  描述：

  乙基-4-异叠酸苯酯 、 3,5-dimethyl-5-hexene-1,3-diol 以 甲苯 为溶剂， 以99%的产率得到Ethyl 4-[(3-hydroxy-3,5-dimethylhex-5-enoxy)carbonylamino]benzoate
  参考文献：
  名称：

  Development of a genetic selection for catalytic antibodies

  摘要：

  The design and evaluation of a new genetic selection system for evolving catalytic antibodies with aldolase activity are described. Through a series of model selections, we have identified selection conditions where expression of a catalytically active antibody confers a growth advantage to Escherichia coli. In addition, we provide evidence that the growth advantage is a direct result of catalytic activity. (C) 2002 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(02)00198-1

文献信息

• Development of a genetic selection for catalytic antibodies
  作者：Jeff Gildersleeve、Jeff Janes、Helle Ulrich、Priscilla Yang、Carlos Barbas、Peter G. Schultz

  DOI：10.1016/s0960-894x(02)00198-1

  日期：2002.6

  The design and evaluation of a new genetic selection system for evolving catalytic antibodies with aldolase activity are described. Through a series of model selections, we have identified selection conditions where expression of a catalytically active antibody confers a growth advantage to Escherichia coli. In addition, we provide evidence that the growth advantage is a direct result of catalytic activity. (C) 2002 Published by Elsevier Science Ltd.