N-(5-benzo[1,3]dioxol-5-ylmethylene-4-oxo-thiazolidin-2-ylidene)benzenesulfonamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(5-benzo[1,3]dioxol-5-ylmethylene-4-oxo-thiazolidin-2-ylidene)benzenesulfonamide
• 英文别名: N-[(5Z)-5-(1,3-benzodioxol-5-ylmethylidene)-4-oxo-1,3-thiazolidin-2-ylidene]benzenesulfonamide
• 化学式: C₁₇H₁₂N₂O₅S₂
• 分子量: 388.425
• InChiKey: WLBJPUQFDMSLNC-DHDCSXOGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  128
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• 2-Imino-4-(thio)oxo-5-poly cyclovinylazolines for use as p13 kinase ihibitors
  申请人：Rueckle Thomas

  公开号：US20070021447A1

  公开（公告）日：2007-01-25

  The present invention is related to 2-imino-azolinone-vinyl fused-benzene derivatives of Formula (1) in particular for the treatment and/or prophylaxis of autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, kidney diseases, platelet aggregation, cancer, transplantation, graft rejection or lung injuries.

  本发明涉及公式（1）的2-亚氨基-咪唑酮-乙烯基融合苯衍生物，特别用于治疗和/或预防自身免疫性疾病和/或炎症性疾病、心血管疾病、神经退行性疾病、肾脏疾病、血小板聚集、癌症、移植、移植排斥或肺损伤。
• 2-IMINO-4-(THIO)OXO-5-POLYCYCLOVINYLAZOLINES FOR USE AS PI3 KINASE INHIBITORS
  申请人：Merck Serono SA

  公开号：EP1648452B1

  公开（公告）日：2009-07-22
• PI3 KINASE GAMMA INHIBITORS FOR THE TREATMENT OF ANAEMIA
  申请人：Applied Research Systems ARS Holding N.V.

  公开号：EP1807075A2

  公开（公告）日：2007-07-18
• P13 kinase gamma inhibitors for the treatment of anaemia
  申请人：Wetzker Reinhard

  公开号：US20090042773A1

  公开（公告）日：2009-02-12

  This present invention is related to the use of selective PD Kinase gamma inhibitors for the manufacture of a medicament for the treatment of disorders related to erythrocyte deficiency. Specifically, the present invention is related to the use of selective PI3 Kinase gamma inhibitors, e.g. substituted azolidinone-vinyl fused-benzene derivatives for the treatment of an anaemia, including haemolytic anaemia, aplastic anaemia and pure red cell anaemia. (I) wherein A, X, Y 1 , Y 2 , Z, n, R 1 and R 2 are described in details in the description hereinafter.
• US8106214B2
  申请人：——

  公开号：US8106214B2

  公开（公告）日：2012-01-31