3-[(5Z)-5-{[5-(3-Nitrophenyl)furan-2-YL]methylidene}-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-YL]propanoic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-[(5Z)-5-{[5-(3-Nitrophenyl)furan-2-YL]methylidene}-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-YL]propanoic acid
• 英文别名: 3-[(5Z)-5-[[5-(3-nitrophenyl)furan-2-yl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]propanoic acid
• 化学式: C17H12N2O6S2
• 分子量: 404.4
• InChiKey: YDVVFXGGKIVZLQ-ZROIWOOFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  174
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• NOVEL RHODANINE DERIVATIVES, METHOD FOR PREPARING SAME, AND PAHRMACEUTICAL COMPOSITION FOR THE PREVENTION OR TREATMENT OF AIDS CONTAINING THE RHODANINE DERIVATIVES AS ACTIVE INGREDIENTS
  申请人：You Ji Chang

  公开号：US20130096125A1

  公开（公告）日：2013-04-18

  Disclosed are novel rhodanine derivatives which are inhibitory of HIV activity. Also provided are a method for preparing the novel rhodanine derivatives, and a pharmaceutical composition for the prevention or treatment of AIDS containing the rhodanine derivatives as active ingredients. Having high inhibitory activity against HIV, the rhodanine derivatives can be effectively used in the prophylaxis or therapy of AIDS.

  揭示了一种新颖的罗丹宁衍生物，对HIV活性具有抑制作用。还提供了一种制备这种新颖罗丹宁衍生物的方法，以及一种包含罗丹宁衍生物作为活性成分的用于预防或治疗艾滋病的药物组合物。罗丹宁衍生物对HIV具有高抑制活性，可以有效用于艾滋病的预防或治疗。
• PHARMACEUTICAL COMPOSITION FOR PREVENTING, ALLEVIATING OR TREATING OSTEOARTHRITIS, CONTAINING RHODANINE DERIVATIVE AS ACTIVE INGREDIENT
  申请人：Avixgen Inc.

  公开号：US20210228548A1

  公开（公告）日：2021-07-29

  The present disclosure relates to the use of a rhodanine derivative in the prevention, amelioration or treatment of osteoarthritis. The rhodanine derivative according to the present disclosure has excellent effects of rescuing the loss of the cartilage matrix and alleviating synovitis, and thus may be effectively used for the prevention, amelioration or treatment of osteoarthritis.