3,6-diamino-4-(4-chloro-phenyl)-5-cyano-thieno[2,3-b]pyridine-2-carboxylic acid amide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3,6-diamino-4-(4-chloro-phenyl)-5-cyano-thieno[2,3-b]pyridine-2-carboxylic acid amide
• 英文别名: 2-aminocarbonyl-3,6-diamino-5-cyano-4-(4-chloro-phenyl)-thieno[2,3-b]pyridine；3,6-Diamino-4-(4-chlorophenyl)-5-cyanothieno[2,3-b]pyridine-2-carboxamide
• 化学式: C₁₅H₁₀ClN₅OS
• 分子量: 343.796
• InChiKey: DHJPTCOCQOYLAD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  160
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• [EN] NOVEL HETEROCYCLIC COMPOUNDS AS IKK2 INHIBITORS WITH ANTI-HBV ACTIVITY<br/>[FR] NOUVEAUX COMPOSES HETEROCYCLIQUES UTILISES COMME INHIBITEURS ET PRESENTANT UNE ACTIVITE ANTI-HBV
  申请人：RIBAPHARM INC

  公开号：WO2005058315A1

  公开（公告）日：2005-06-30

  This application relates to novel thienopyridines of Formula (I), which are IKK inhibitors and are useful for treating Hepatitis B infection and other diseases. This application also relates to pharmaceutical compositions comprising thienopyridines and the use of such compositions to treat Hepatitis B and other diseases.

  本发明涉及公式（I）的新型噻吩并吡啶类化合物，其为IKK抑制剂并且可用于治疗乙型肝炎感染及其他疾病。本发明还涉及包含噻吩并吡啶类化合物的制药组合物以及使用这种组合物治疗乙型肝炎和其他疾病的方法。
• Pyridothiophene Compounds
  申请人：Drysdale James Martin

  公开号：US20070213328A1

  公开（公告）日：2007-09-13

  The use of compounds of formula (I) in therapy, particularly for the treatment of a disorder mediated by excessive or inappropriate HSP90 activity formula (I), wherein R 2 is a group of formula (IA): -(Ar 1 ) m -(Alk 1 ) p -(Z) r -(Alk 2 ) s -Q (IA) Ar 1 , Alk 1 , Z, Alk 2 and Q being as defined in the specification; m, p, r and s are independently 0 or 1; R 3 is hydrogen, an optional substituent, or an optionally substituted (C 1 -C 6 )alkyl, aryl or heteroaryl radical; and R 4 is a carboxylic ester, carboxamide or sulfonamide group; or a salt, N-oxide, hydrate, or solvate thereof.

  公式（I）化合物在治疗中的应用，特别是用于治疗由过度或不适当的HSP90活性导致的疾病，其中R2是公式（IA）的基团：-(Ar1)m-(Alk1)p-(Z)r-(Alk2)s-Q（IA）Ar1，Alk1，Z，Alk2和Q在规范中定义；m，p，r和s独立地为0或1；R3是氢，可选取代基或可选取代的（C1-C6）烷基，芳基或杂环芳基基团；R4是羧酸酯，羧酰胺或磺酰胺基团；或其盐，N-氧化物，水合物或溶剂化物。
• THIENOPYRIDINDERIVATE UND IHRE VERWENDUNG ALS HSP90 MODULATOREN
  申请人：Merck Patent GmbH

  公开号：EP1853609A1

  公开（公告）日：2007-11-14
• Thienopyridine Derivatives and the Use Thereof as Hsp90 Modulators
  申请人：Eggenweiler Hans-Michael

  公开号：US20090054452A1

  公开（公告）日：2009-02-26

  Novel thienopyridine derivatives of the formula (I), in which R 1 , R 2 , R 3 and Y have the meanings indicated in Claim 1 , are HSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role.
• US7943637B2
  申请人：——

  公开号：US7943637B2

  公开（公告）日：2011-05-17