[2-Amino-4-(azidomethyl)phenyl]methanethiol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [2-Amino-4-(azidomethyl)phenyl]methanethiol
• 英文别名: [2-amino-4-(azidomethyl)phenyl]methanethiol
• 化学式: C8H10N4S
• 分子量: 194.26
• InChiKey: JKPOFEKOKHBZQP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  41.4
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• METHODS AND COMPOSITIONS FOR SITE-SPECIFIC LABELING OF PEPTIDES AND PROTEINS
  申请人：UNIVERSITY OF ROCHESTER

  公开号：US20150241440A1

  公开（公告）日：2015-08-27

  Methods and compositions are provided for covalently linking a chemical species to a recombinant or synthetic polypeptide. The methods involve the reaction of a thioester-comprising polypeptide with a reagent comprising a reactive amino-thiol group connected to the chemical species which is to be covalently linked to the polypeptide, via a linker. Such chemical species can be a functional group, a label or tag molecule, a biological molecule, a ligand, or a solid support. Efficient and catalyst-free methods for C-terminal protein labeling are also provided. The methods expand current capabilities in the area of protein functionalization, providing useful and complementary tools for the isolation, detection, characterization, and analysis of proteins in a variety of in vitro and in vivo applications.

  提供了一种将化学物种与重组或合成多肽共价连接的方法和组合物。该方法涉及将含硫酯的多肽与含有与化学物种连接的反应性氨基硫基团的试剂发生反应，该化学物种通过连接剂与多肽共价连接。这种化学物种可以是功能基团、标签或标记分子、生物分子、配体或固体支持。还提供了高效且无催化剂的C末端蛋白标记方法。这些方法扩展了当前蛋白质功能化领域的能力，为在各种体外和体内应用中蛋白质的分离、检测、表征和分析提供了有用且互补的工具。
• US9557336B2
  申请人：——

  公开号：US9557336B2

  公开（公告）日：2017-01-31
• [EN] METHODS AND COMPOSITIONS FOR SITE-SPECIFIC LABELING OF PEPTIDES AND PROTEINS<br/>[FR] PROCÉDÉS ET COMPOSITIONS POUR LE MARQUAGE SPÉCIFIQUE D'UN SITE DE PEPTIDES ET DE PROTÉINES
  申请人：UNIV ROCHESTER

  公开号：WO2014039715A1

  公开（公告）日：2014-03-13

  Methods and compositions are provided for covalently linking a chemical species to a recombinant or synthetic polypeptide. The methods involve the reaction of a thioester-comprising polypeptide with a reagent comprising a reactive amino-thiol group connected to the chemical species which is to be covalently linked to the polypeptide, via a linker. Such chemical species can be a functional group, a label or tag molecule, a biological molecule, a ligand, or a solid support. Efficient and catalyst-free methods for C-terminal protein labeling are also provided. The methods expand current capabilities in the area of protein functionalization, providing useful and complementary tools for the isolation, detection, characterization, and analysis of proteins in a variety of in vitro and in vivo applications.