2-Hydroxybenzaldehyde;pyridine-4-carbohydrazide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-Hydroxybenzaldehyde;pyridine-4-carbohydrazide
• 英文别名: 2-hydroxybenzaldehyde;pyridine-4-carbohydrazide
• 化学式: C13H13N3O3
• 分子量: 259.26
• InChiKey: OGWOMSANEWBACU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.89
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  105
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Mitochondrial lipid permeable iron chelators for treating and preventing ischemia/reperfusion (I/R) injury in the heart following an ischemic event
  申请人：Northwestern University

  公开号：US10258612B2

  公开（公告）日：2019-04-16

  Disclosed are methods and compositions for treating or preventing a disease or disorder responsive to a decrease in baseline mitochondrial iron in a subject in need thereof. The methods typically include administering a pharmaceutical composition comprising a mitochondrial permeable iron chelator to the subject.

  本发明公开了治疗或预防疾病或失调的方法和组合物，这些疾病或失调对有需要的受试者线粒体基线铁的减少有反应。这些方法通常包括向受试者施用包含线粒体可渗透铁螯合剂的药物组合物。
• HIF-1 modulator paint formulation and uses thereof
  申请人：The Board of Trustees of the Leland Stanford Junior University

  公开号：US10220009B2

  公开（公告）日：2019-03-05

  Formulations and methods are provided for improving the function, i.e. clinical outcome, of solid organ transplants. Lung transplantation is of particular interest. In the methods of the invention, a nanoparticle formulation comprising an effective dose of an iron chelator active agent in nanoparticle form, including without limitation, deferoxamine (DFO), deferasirox (DFX), and deferiprone (DFP), etc. suspended in a carrier compatible with the tissue of interest, is topically applied to the surface of tissues at the site of anastomosis. The nanoparticles are comprised of the active agent and a pharmaceutically acceptable stabilizer.

  为改善实体器官移植的功能（即临床结果）提供了制剂和方法。肺移植尤其值得关注。在本发明的方法中，一种纳米颗粒制剂包括有效剂量的纳米颗粒形式的铁螯合剂活性剂，包括但不限于悬浮在与相关组织相容的载体中的去铁胺（DFO）、去铁胺（DFX）和去铁酮（DFP）等，局部应用于吻合部位的组织表面。纳米颗粒由活性剂和药学上可接受的稳定剂组成。
• Use of mitochondrial iron chelators for treatment of chronic obstructive pulmonary disease
  申请人：Cornell University

  公开号：US10905682B2

  公开（公告）日：2021-02-02

  A method for treating one or more symptoms of COPD comprising administering to an in need of treatment a therapeutically effect amount of one or more mitochondrial iron chelators. The mitochondrial iron chelator can be deferiprone. Compostions comprising mitochondrial iron chelators suitable for administration are also disclosed.

  一种治疗慢性阻塞性肺病的一种或多种症状的方法，包括向需要治疗者施用治疗效果量的一种或多种线粒体铁螯合剂。线粒体铁螯合剂可以是去铁酮。此外，还公开了包含适于施用的线粒体铁螯合剂的复合物。
• Succinate dehydrogenase inhibitor containing compositions
  申请人：ARCH WOOD PROTECTION, INC

  公开号：US10829648B2

  公开（公告）日：2020-11-10

  A composition containing succinate dehydrogenase inhibitor and a potentiator has been discovered to enhance the activity of the succinate dehydrogenase such that the amount of the succinate dehydrogenase inhibitor need to effectively treat a microbial substance can be reduced substantially. The compositions may be used as additives for paints and coatings, and protecting crops, seeds, wallboard, metal working fluids, wood from mold, fungi and other microbes.

  现已发现一种含有琥珀酸脱氢酶抑制剂和增效剂的组合物，可增强琥珀酸脱氢酶的活性，从而大幅减少有效处理微生物物质所需的琥珀酸脱氢酶抑制剂用量。这些组合物可用作油漆和涂料的添加剂，保护农作物、种子、墙板、金属加工液、木材免受霉菌、真菌和其他微生物的侵害。
• SUCCINATE DEHYDROGENASE INHIBITOR CONTAINING COMPOSITIONS
  申请人：Arch Wood Protection, Inc.

  公开号：EP2919586A1

  公开（公告）日：2015-09-23