Methyl 2,6-bis(methylsulfonyl)-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Methyl 2,6-bis(methylsulfonyl)-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate
• 英文别名: methyl 2,6-bis(methylsulfonyl)-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate
• 化学式: C16H15F3N2O8S2
• 分子量: 484.4
• InChiKey: RCZQLLGKBRBKJU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  31
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  169
• 氢给体数：
  1
• 氢受体数：
  12

文献信息

• [EN] METHODS TO INHIBIT INTRACELLULAR GROWTH OF BACTERIA AND TO TREAT BACTERIA-MEDIATED DISEASES<br/>[FR] MÉTHODES D'INHIBITION DE LA CROISSANCE INTRACELLULAIRE DE BACTÉRIES ET DE TRAITEMENT DE MALADIES D'ORIGINE BACTÉRIENNE
  申请人：AGENCY SCIENCE TECH & RES

  公开号：WO2014039011A1

  公开（公告）日：2014-03-13

  Disclosed is a method of preventing, treating or inhibiting bacterial infections. The method comprises administering at least one of the compounds disclosed herein. Also disclosed are methods of increasing acidity of bacterial phagosomes to inhibit bacterial growth, methods of increasing mitochondrial reactive oxygen species (mROS) generation to inhibit bacterial growth in a cell, pharmaceutical compositions and uses thereof.