2-[[3-[Bis[(2-methylpropan-2-yl)oxycarbonyl]amino]-6-bromo-2-methoxycarbonylphenoxy]methyl]-2,5-dihydropyrrole-1-carboxylic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[[3-[Bis[(2-methylpropan-2-yl)oxycarbonyl]amino]-6-bromo-2-methoxycarbonylphenoxy]methyl]-2,5-dihydropyrrole-1-carboxylic acid
• 英文别名: 2-[[3-[bis[(2-methylpropan-2-yl)oxycarbonyl]amino]-6-bromo-2-methoxycarbonylphenoxy]methyl]-2,5-dihydropyrrole-1-carboxylic acid
• 化学式: C₂₄H₃₁BrN₂O₉
• 分子量: 571.4
• InChiKey: KFWSJWURUKWVJU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  36
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  132
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• Tricyclic Pyrazole Sulphonamide Compounds and Methods of Making and Using Same
  申请人：Cramp Susan Mary

  公开号：US20140080822A1

  公开（公告）日：2014-03-20

  The invention provides tricyclic sulfonamide compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tricyclic compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.

  本发明提供了三环磺酰胺化合物及其在治疗医学疾病（如肥胖症）中的应用。本发明还提供了制备各种三环化合物的制药组合物和方法。预计这些化合物对甲硫氨酸氨肽酶2具有活性。
• TRICYCLIC PYRAZOLE SULFONAMIDE COMPOUNDS AND METHODS OF MAKING AND USING SAME
  申请人：Zafgen, Inc.

  公开号：EP2705035B1

  公开（公告）日：2016-12-14
• TRICYCLIC PYRAZOLE SULPHONAMIDE COMPOUNDS AND METHODS OF MAKING AND USING SAME
  申请人：Zafgen, Inc.

  公开号：US20160324865A1

  公开（公告）日：2016-11-10

  The invention provides tricyclic sulfonamide compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tricyclic compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
• US9242997B2
  申请人：——

  公开号：US9242997B2

  公开（公告）日：2016-01-26