3-Phenyloxaziridin-3-ol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-Phenyloxaziridin-3-ol
• 英文别名: 3-phenyloxaziridin-3-ol
• 化学式: C₇H₇NO₂
• 分子量: 137.14
• InChiKey: ITHGLJOUBUBTNB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  54.7
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Compositions comprising an internalizing nucleic acid molecule, and their methods of use
  申请人：B3 BIO, INC.

  公开号：US10059950B2

  公开（公告）日：2018-08-28

  Provided are internalizing nucleic acid molecules (“iNA”) that can bind and internalize into target cells containing a cell surface molecule to which the iNA can bind; an iNA further modified to include at least one chemical modification, wherein the at least one modification is selected from the group consisting of a chemical substitution in the nucleic acid sequence of the iNA, incorporation of a modified nucleotide into the iNA, conjugation to a linker, and conjugation to at least one effector moiety comprising one or more of a drug or a detectable moiety or a combination thereof; and methods of using modified iNA to deliver at least one effector moiety into the target cells.

  本发明提供了内化核酸分子（"iNA"），它能与含有细胞表面分子的靶细胞结合并内化到靶细胞中；进一步修饰以包括至少一种化学修饰的 iNA，其中至少一种修饰选自由 iNA 核酸序列中的化学取代、将修饰的核苷酸掺入 iNA、与连接体连接、与至少一种效应分子连接，该效应分子包括药物或可检测分子中的一种或多种或其组合；以及使用修饰的 iNA 将至少一种效应分子递送到靶细胞中的方法。
• Gold porphyrin-PEG conjugates and methods of use
  申请人：The University of Hong Kong

  公开号：US11135310B2

  公开（公告）日：2021-10-05

  Disclosed are conjugates, compositions, and methods that include or use one or more gold(III) porphyrin complexes. Preferred conjugates are gold(III) porphyrin-poly(ethylene glycol) (PEG) conjugates. Preferred compositions and methods include or use such gold(III) porphyrin-PEG conjugates. Disclosed is a method for treatment of cancer comprising administering to a human in need of such treatment a composition containing a therapeutically effective amount of gold(III) porphyrin-poly(ethylene glycol) (PEG) conjugates. The gold(III) porphyrin-PEG conjugates can be in the form of nanostructures formed by self-assembly of the gold(III) porphyrin-PEG conjugates; or nanocomposites formed by encapsulation of other therapeutic agents by the nanostructures of gold(III) porphyrin-PEG conjugates.

  公开了包括或使用一种或多种金（III）卟啉络合物的共轭物、组合物和方法。优选的共轭物是金（III）卟啉-聚乙二醇（PEG）共轭物。优选的组合物和方法包括或使用这种金（III）卟啉-聚乙二醇（PEG）共轭物。公开了一种治疗癌症的方法，该方法包括向需要治疗的人施用含有治疗有效量的金(III)卟啉-聚乙二醇(PEG)共轭物的组合物。金（III）卟啉-聚乙二醇（PEG）共轭物可以是金（III）卟啉-聚乙二醇（PEG）共轭物自组装形成的纳米结构形式；或者是金（III）卟啉-聚乙二醇（PEG）共轭物的纳米结构包裹其他治疗剂形成的纳米复合材料。
• COMPOSITIONS COMPRISING AN INTERNALIZING NUCLEIC ACID MOLECULE, AND THEIR METHODS OF USE
  申请人：E3 Group

  公开号：EP2839002A2

  公开（公告）日：2015-02-25
• GOLD PORPHYRIN-PEG CONJUGATES AND METHODS OF USE
  申请人：The University of Hong Kong

  公开号：EP3386986A1

  公开（公告）日：2018-10-17
• Nanoparticles for Delivery of Agents to Glioblastoma Tumors
  申请人：Nanoforma Inc.

  公开号：US20170326252A1

  公开（公告）日：2017-11-16

  The present invention is, in general, directed to nanoparticles for the delivery of agents to glioblastoma tumors. More particularly, the present invention relates to nanoparticle conjugates that deliver and release agents to a glioblastoma tumor. The invention is also directed to methods of delivering agents to glioblastoma tumors.