4-(2-methyl-4-nitrophenyl)-3,6-dihydro-2H-pyridine-1-carboxylate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(2-methyl-4-nitrophenyl)-3,6-dihydro-2H-pyridine-1-carboxylate
• 化学式: C13H13N2O4-
• 分子量: 261.25
• InChiKey: CWHHGNISMZGQBW-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  89.2
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• VEGFR3 INHIBITORS
  申请人：CANCER THERAPEUTICS CRC PTY LIMITED

  公开号：US20140080798A1

  公开（公告）日：2014-03-20

  This invention relates to compounds of the formula (I): The invention also relates to processes for the preparation of the compound of the formula (I), pharmaceutical agents or compositions containing the compound or a method of using the compound for the treatment of proliferative diseases, such as cancer, as well as the treatment of diseases ameliorated by the control and/or inhibition of lymphangiogenesis.

  本发明涉及公式（I）的化合物。该发明还涉及制备公式（I）化合物的方法，含有该化合物的药物制剂或组合物，或使用该化合物治疗增生性疾病（如癌症）以及通过控制和/或抑制淋巴管生成改善疾病的方法。
• Pyrimidopyrimidinones useful as wee-1 kinase inhibitors
  申请人：ALMAC DISCOVERY LIMITED

  公开号：US11208413B2

  公开（公告）日：2021-12-28

  The present invention relates to a compound that is useful as an inhibitor of the activity of Wee-1 kinase. The present invention also relates to pharmaceutical compositions comprising this compound and to methods of using this compound in the treatment of cancer and methods of treating cancer.

  本发明涉及一种可用作 Wee-1 激酶活性抑制剂的化合物。本发明还涉及包含这种化合物的药物组合物，以及使用这种化合物治疗癌症的方法和治疗癌症的方法。
• AMINOTRIAZINE DERIVATIVES USEFUL AS TANK-BINDING KINASE INHIBITOR COMPOUNDS
  申请人：Gilead Sciences, Inc.

  公开号：EP3197884A1

  公开（公告）日：2017-08-02
• PYRIMIDOPYRIMIDINONES USEFUL AS WEE-1 KINASE INHIBITORS
  申请人：Almac Discovery Limited

  公开号：EP3592745B1

  公开（公告）日：2021-07-28
• US9266864B2
  申请人：——

  公开号：US9266864B2

  公开（公告）日：2016-02-23