(Z)-but-2-enedioic acid;(2R)-2-[2-[(1R)-1-(4-chlorophenyl)-1-phenylethoxy]ethyl]-1-methylpyrrolidine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (Z)-but-2-enedioic acid;(2R)-2-[2-[(1R)-1-(4-chlorophenyl)-1-phenylethoxy]ethyl]-1-methylpyrrolidine
• 化学式: C25H30ClNO5
• 分子量: 460.0
• InChiKey: PMGQWSIVQFOFOQ-QARCBVEASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.82
• 重原子数：
  32
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  87.1
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• ORAL FORMULATION
  申请人：Otsuka Pharmaceutical Co., Limited

  公开号：EP2844232A1

  公开（公告）日：2015-03-11
• Oral Formulation
  申请人：OTSUKA PHARMACEUTICAL CO., LTD.

  公开号：US20150126521A1

  公开（公告）日：2015-05-07

  Provided are an oral formulation capable of improving easy administrability and showing good preservation stability, and a substrate for oral formulation. An oral formulation containing a medicament; sugar alcohol; one or more kinds of hydrophilic polysaccharides selected from the group consisting of acacia, pullulan and maltodextrin; a gelling agent; and water, and a substrate for oral formulation, which contains sugar alcohol; the above-mentioned hydrophilic polysaccharides; a gelling agent; and water.
• [EN] ORAL FORMULATION<br/>[FR] FORMULATION ORALE
  申请人：OTSUKA PHARMA CO LTD

  公开号：WO2013165021A1

  公开（公告）日：2013-11-07

  Provided are an oral formulation capable of improving easy administrability and showing good preservation stability, and a substrate for oral formulation. An oral formulation containing a medicament; sugar alcohol; one or more kinds of hydrophilic polysaccharides selected from the group consisting of acacia, pullulan and maltodextrin; a gelling agent; and water, and a substrate for oral formulation, which contains sugar alcohol; the above-mentioned hydrophilic polysaccharides; a gelling agent; and water.