1,3-thiazol-5-ylmethyl N-[(2S,3S,5S)-3-hydroxy-5-[[(2S)-3-methyl-2-[[methyl-[(2-propan-2-yl-1,3-thiazol-4-yl)methyl]carbamoyl]amino]butyl]amino]-1,6-diphenylhexan-2-yl]carbamate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,3-thiazol-5-ylmethyl N-[(2S,3S,5S)-3-hydroxy-5-[[(2S)-3-methyl-2-[[methyl-[(2-propan-2-yl-1,3-thiazol-4-yl)methyl]carbamoyl]amino]butyl]amino]-1,6-diphenylhexan-2-yl]carbamate
• 化学式: C₃₇H₅₀N₆O₄S₂
• 分子量: 707.0
• InChiKey: IQKGTTKNEORYDQ-LBFSXKFDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  49
• 可旋转键数：
  19
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  185
• 氢给体数：
  4
• 氢受体数：
  9

文献信息

• ANTIRETROVIRAL COMPOSITION
  申请人：Cipla Limited

  公开号：EP2844231A1

  公开（公告）日：2015-03-11
• UNIT DOSAGE FORM COMPRISING EMTRICITABINE, TENOFOVIR, DARUNAVIR AND RITONAVIR
  申请人：Teva Pharmaceutical Industries Ltd

  公开号：EP3129009A1

  公开（公告）日：2017-02-15
• [EN] ANTIRETROVIRAL COMPOSITION<br/>[FR] COMPOSITION ANTIRÉTROVIRALE
  申请人：CIPLA LTD

  公开号：WO2013164559A1

  公开（公告）日：2013-11-07

  The present invention provides a pharmaceutical solid oral sprinkle composition comprising one or more antiretroviral drugs, and a method of manufacturing the same. The present invention is particularly useful for treatment of an HIV infection, AIDS related complex, or AIDS.
• [EN] PHARMACEUTICAL COMBINATIONS AGAINST CO-INFECTION WITH HIV AND TUBERCULOSIS<br/>[FR] COMBINAISONS PHARMACEUTIQUES CONTRE UNE CO-INFECTION PAR LE VIH ET LA TUBERCULOSE
  申请人：GILEAD SCIENCES INC

  公开号：WO2015120057A1

  公开（公告）日：2015-08-13

  The disclosure describes methods for treatment of patients co-infected with HIV and tuberculosis, wherein the patient receives effective amounts of elvitegravir, an antimycobacterial agent and a CYP inhibitor.
• [EN] UNIT DOSAGE FORM COMPRISING EMTRICITABINE, TENOFOVIR, DARUNAVIR AND RITONAVIR<br/>[FR] FORME PHARMACEUTIQUE UNITAIRE COMPRENANT DE L'EMTRICITABINE, DU TÉNOFOVIR, DU DARUNAVIR ET DU RITONAVIR
  申请人：TEVA PHARMA

  公开号：WO2015155673A1

  公开（公告）日：2015-10-15

  The present invention relates to an oral unit dosage form comprising Emtricitabine, Tenofovir, Darunavir and Ritonavir and a monolithic tablet comprising Darunavir and Ritonavir and their use to treat HIV infection.