[2-(5-Bromopyridin-2-yl)-5-(furan-2-yl)pyrazol-3-yl]methanol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: [2-(5-Bromopyridin-2-yl)-5-(furan-2-yl)pyrazol-3-yl]methanol
• 英文别名: [2-(5-bromopyridin-2-yl)-5-(furan-2-yl)pyrazol-3-yl]methanol
• 化学式: C₁₃H₁₀BrN₃O₂
• 分子量: 320.14
• InChiKey: JNSDOPZWQWETPC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  64.1
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• SUBSTITUTED PYRAZOLE COMPOUNDS AS CRAC MODULATORS
  申请人：LUPIN LIMITED

  公开号：US20150111925A1

  公开（公告）日：2015-04-23

  The present invention relates to compounds described herein Formula (I) and pharmaceutical acceptable salts thereof, which modulate the activity of calcium release-activated calcium (CRAC) channel. The invention also describes the compounds of Formula (I) and pharmaceutical compositions containing such compounds thereof for treating, managing, and/or lessening the severity of diseases, disorders, syndromes or conditions associated with the modulation of calcium release-activated calcium (CRAC) channel.

  本发明涉及描述如下式（I）的化合物及其药学上可接受的盐，其调节钙释放活化的钙（CRAC）通道的活性。本发明还描述了式（I）的化合物及其药物组合物，用于治疗、管理和/或减轻与调节钙释放活化的钙（CRAC）通道相关的疾病、疾病、综合征或病状。
• US9409898B2
  申请人：——

  公开号：US9409898B2

  公开（公告）日：2016-08-09
• [EN] SUBSTITUTED PYRAZOLE COMPOUNDS AS CRAC MODULATORS<br/>[FR] COMPOSÉS SUBSTITUÉS DE PYRAZOLE EN TANT QUE MODULATEURS DE CRAC
  申请人：LUPIN LTD

  公开号：WO2013164773A1

  公开（公告）日：2013-11-07

  The present invention relates to compounds described herein Formula (I) and pharmaceutical acceptable salts thereof, which modulate the activity of calcium release- activated calcium (CRAC) channel. The invention also describes the compounds of Formula (I) and pharmaceutical compositions containing such compounds thereof for treating, managing, and/or lessening the severity of diseases, disorders, syndromes or conditions associated with the modulation of calcium release-activated calcium (CRAC) channel.