2-[(2,4-Dimethoxyphenyl)methyl]-1,2-thiazolidine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[(2,4-Dimethoxyphenyl)methyl]-1,2-thiazolidine
• 英文别名: 2-[(2,4-dimethoxyphenyl)methyl]-1,2-thiazolidine
• 化学式: C₁₂H₁₇NO₂S
• 分子量: 239.34
• InChiKey: CZHMVMPNAXFQCA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  47
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Carbazole-containing sulfonamides as cryptochrome modulators
  申请人：Reset Therapeutics, Inc.

  公开号：US10383880B2

  公开（公告）日：2019-08-20

  The subject matter herein is directed to carbazole-containing sulfonamide derivatives and pharmaceutically acceptable salts or hydrates thereof of structural formula I wherein the variable R1, R2, R3, R4, R5, R6, R7, A, B, C′, D, E, F, G, H′, a, and b are accordingly described. Also provided are pharmaceutical compositions comprising the compounds of formula I to treat a Cry-mediated disease or disorder, such as diabetes, obesity, metabolic syndrome, Cushing's syndrome, and glaucoma.

  本发明的主题涉及结构式I的含咔唑磺酰胺衍生物及其药学上可接受的盐或水合物，其中相应地描述了变量R1、R2、R3、R4、R5、R6、R7、A、B、C′、D、E、F、G、H′、a和b。还提供了包含式 I 化合物的药物组合物，用于治疗 Cry 介导的疾病或紊乱，如糖尿病、肥胖症、代谢综合征、库欣综合征和青光眼。
• CARBAZOLE-CONTAINING SULFONAMIDES AS CRYPTOCHROME MODULATORS
  申请人：Reset Therapeutics, Inc.

  公开号：EP2855458B1

  公开（公告）日：2018-08-08
• US9775845B2
  申请人：——

  公开号：US9775845B2

  公开（公告）日：2017-10-03
• [EN] CARBAZOLE-CONTAINING SULFONAMIDES AS CRYPTOCHROME MODULATORS<br/>[FR] SULFONAMIDES CONTENANT DU CARBAZOLE EN TANT QUE MODULATEURS DE CRYPTOCHROME
  申请人：RESET THERAPEUTICS INC

  公开号：WO2013170186A1

  公开（公告）日：2013-11-14

  The subject matter herein is directed to carbazole-containing sulfonamide derivatives and pharmaceutically acceptable salts or hydrates thereof of structural formula I wherein the variable R1, R2, R3, R4, R5, R6, R7, A, B, C, D, E, F, G, H, a, and b are accordingly described. Also provided are pharmaceutical compositions comprising the compounds of formula I to treat a Cry-mediated disease or disorder, such as diabetes, obesity, metabolic syndrome, Cushing' s syndrome, and glaucoma.