(3E,5Z,8S,9Z,13Z,15E,18S)-3-ethyl-8-hydroxy-18-[(1R)-1-hydroxyethyl]-9,13,15-trimethyl-1-oxacyclooctadeca-3,5,9,13,15-pentaen-2-one

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酯类和类似物
• 英文名称: (3E,5Z,8S,9Z,13Z,15E,18S)-3-ethyl-8-hydroxy-18-[(1R)-1-hydroxyethyl]-9,13,15-trimethyl-1-oxacyclooctadeca-3,5,9,13,15-pentaen-2-one
• 化学式: C₂₄H₃₆O₄
• 分子量: 388.5
• InChiKey: DKMVCQBEIJJBAU-IJYDEIHOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  28
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• SOLID STATE FORMS OF FIDAXOMYCIN AND PROCESSES FOR PREPARATION THEREOF
  申请人：Teva Pharmaceutical Works Ltd.

  公开号：EP2855499A1

  公开（公告）日：2015-04-08
• [EN] SOLID STATE FORMS OF FIDAXOMYCIN AND PROCESSES FOR PREPARATION THEREOF<br/>[FR] FORMES À L'ÉTAT SOLIDE DE FIDAXOMYCINE ET PROCÉDÉS POUR LA PRÉPARATION DE CELLES-CI
  申请人：TEVA PHARMACEUTICAL WORKS LTD

  公开号：WO2013170142A1

  公开（公告）日：2013-11-14

  The present invention provides solid state forms of Fidaxomycin, processes for preparing the solid state forms, as well as pharmaceutical compositions and formulations comprising one or more of the solid state forms of Fidaxomycin, and processes for the preparation of of the compositions and formulations. The solid state forms of the present invention exhibit advantageous properties such as improved reliability and reproducibility manufacturing and processing and stability in formulations.