[(2R,3R,4S,5R)-3,4,5-tribenzoyloxy-6-hydroxyoxan-2-yl]methyl benzoate;2,2,2-trichloroacetamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [(2R,3R,4S,5R)-3,4,5-tribenzoyloxy-6-hydroxyoxan-2-yl]methyl benzoate;2,2,2-trichloroacetamide
• 化学式: C36H30Cl3NO11
• 分子量: 759.0
• InChiKey: KPKNTLVXQYWCQI-ABGSXABXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.08
• 重原子数：
  51
• 可旋转键数：
  13
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  178
• 氢给体数：
  2
• 氢受体数：
  11

文献信息

• [EN] IMPROVED SYNTHESIS<br/>[FR] SYNTHÈSE AMÉLIORÉE
  申请人：ONCOLOGY RES INT LTD

  公开号：WO2013173862A1

  公开（公告）日：2013-11-28

  The present invention provides an improved synthesis of a class of steroid saponins. Furthermore, the present invention provides a method of selectively discriminating between the C2 and C3 hydroxyl groups of a mono-glycosylated steroid saponin – a key step in the preparation of this class of compounds. Additionally, the present invention provides a range of steroid saponin derivatives, and methods of making them.

  本发明提供了一种改进的类固醇皂苷的合成方法。此外，本发明提供了一种在单糖基固醇皂苷的制备过程中，选择性区分C2和C3羟基的方法，这是这类化合物制备过程中的关键步骤。此外，本发明还提供了一系列类固醇皂苷衍生物及其制备方法。
• [EN] STEROID SAPONINS WITH ANTI-CANCER ACTIVITY<br/>[FR] SAPONINES STÉROÏDIENNES AYANT UNE ACTIVITÉ ANTICANCÉREUSE
  申请人：ONCOLOGY RES INTERNATIONAL LIMITED

  公开号：WO2018145162A1

  公开（公告）日：2018-08-16

  The present invention relates to a new class of steroid saponins that have interesting biological activity. In particular the present invention relates to a class of steroid saponins in which the sugar moiety has been selectively functionalised to introduce a moiety that contains either, (i) a hydrogen ion donor, (ii) a hydrogen ion acceptor or (iii) a combination thereof. These new, water-soluble compounds are found to not only have potent anti-cancer properties per se but also have the ability to promote the immune response in a subject and can thus act as adjuvants for T-cell activation in cancer therapy.

  本发明涉及一类具有有趣生物活性的新类固醇皂苷。具体来说，本发明涉及一类固醇皂苷，其中糖基已被选择性地功能化，以引入含有（i）氢离子给体，（ii）氢离子受体或（iii）二者组合的基团。这些新的水溶性化合物不仅具有强大的抗癌特性，还能促进受试者的免疫反应，并因此可以作为癌症治疗中T细胞激活的辅助剂。
• SYNTHESIS
  申请人：Oncology Research International Limited

  公开号：US20150105543A1

  公开（公告）日：2015-04-16

  The present invention provides an improved synthesis of a class of steroid saponins. Furthermore, the present invention provides a method of selectively discriminating between the C2 and C3 hydroxyl groups of a mono-glycosylated steroid saponin—a key step in the preparation of this class of compounds. Additionally, the present invention provides a range of steroid saponin derivatives, and methods of making them.

  本发明提供了一类类固醇皂苷的改进合成方法。此外，本发明提供了一种选择性区分单糖基类固醇皂苷中C2和C3羟基的方法，这是制备此类化合物的关键步骤。此外，本发明还提供了一系列类固醇皂苷衍生物及其制备方法。
• Steroid saponins with anti-cancer activity
  申请人：Oncology Research International Limited

  公开号：US10925887B2

  公开（公告）日：2021-02-23

  The present invention relates to a new class of steroid saponins that have interesting biological activity. In particular the present invention relates to a class of steroid saponins in which the sugar moiety has been selectively functionalised to introduce a moiety that contains either, (i) a hydrogen ion donor, (ii) a hydrogen ion acceptor or (iii) a combination thereof. These new, water-soluble compounds are found to not only have potent anti-cancer properties per se but also have the ability to promote the immune response in a subject and can thus act as adjuvants for T-cell activation in cancer therapy.

  本发明涉及一类具有有趣生物活性的新型甾体皂甙。特别是本发明涉及一类甾体皂苷，其中的糖分子被选择性地官能化，以引入一个含有(i)氢离子供体、(ii)氢离子受体或(iii)其组合的分子。研究发现，这些新的水溶性化合物不仅本身具有强大的抗癌特性，而且还能促进受试者的免疫反应，因此可以作为癌症治疗中激活 T 细胞的佐剂。
• IMPROVED SYNTHESIS
  申请人：Oncology Research International Limited

  公开号：EP2852607A1

  公开（公告）日：2015-04-01