1-[6-(4-Fluorophenyl)pyridin-3-yl]-3-(1-piperidin-1-ylbutan-2-yl)urea

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1-[6-(4-Fluorophenyl)pyridin-3-yl]-3-(1-piperidin-1-ylbutan-2-yl)urea
• 英文别名: 1-[6-(4-fluorophenyl)pyridin-3-yl]-3-(1-piperidin-1-ylbutan-2-yl)urea
• 化学式: C₂₁H₂₇FN₄O
• 分子量: 370.5
• InChiKey: YPRUQBTZSKBFTF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  57.3
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• COMBINATION COMPRISING PARTHENOLIDE FOR USE IN THE TREATMENT OF ALZHEIMER'S DISEASE AND OTHER NEURODEGENERATIVE DISORDERS
  申请人：King Abdullah University of Science and Technology

  公开号：EP2852382A1

  公开（公告）日：2015-04-01
• [EN] COMBINATION COMPRISING PARTHENOLIDE FOR USE IN THE TREATMENT OF ALZHEIMER'S|DISEASE AND OTHER NEURODEGENERATIVE DISORDERS<br/>[FR] COMBINAISON COMPRENANT DU PARTHENOLIDE POUR LE TRAITEMENT DE LA MALADIE D'ALZHEIMER ET D'AUTRES TROUBLES NEURODÉGÉNÉRATIFS
  申请人：KING ABDULLAH UNIVESITY OF SCIENCE AND TECHNOLOGY

  公开号：WO2013175315A1

  公开（公告）日：2013-11-28

  The present invention generally concerns particular methods and compositions for treatment of a neurodegenerative disease, such as Alzheimer's Disease. In particular embodiments, there is a composition comprising Parthenolide and a second agent, including an inhibitor of TLR4/MD-2/CD14, nAChR agonist, Resatorvid, Curcumin, Tilorone or a Tilorone analog, or a combination thereof.