2-chloro-4-hydroxy-3-(1-hydroxy-5,6,7,8-tetrahydronaphthalen-2-yl)-5-phenyl-7H-thieno[2,3-b]pyridin-6-one;3-[2-chloro-4-hydroxy-6-oxo-3-(5,6,7,8-tetrahydronaphthalen-2-yl)-7H-thieno[2,3-b]pyridin-5-yl]benzonitrile;2-chloro-4-hydroxy-5-pyridin-3-yl-3-(5,6,7,8-tetrahydronaphthalen-2-yl)-7H-thieno[2,3-b]pyridin-6-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-chloro-4-hydroxy-3-(1-hydroxy-5,6,7,8-tetrahydronaphthalen-2-yl)-5-phenyl-7H-thieno[2,3-b]pyridin-6-one;3-[2-chloro-4-hydroxy-6-oxo-3-(5,6,7,8-tetrahydronaphthalen-2-yl)-7H-thieno[2,3-b]pyridin-5-yl]benzonitrile;2-chloro-4-hydroxy-5-pyridin-3-yl-3-(5,6,7,8-tetrahydronaphthalen-2-yl)-7H-thieno[2,3-b]pyridin-6-one
• 化学式: C69H52Cl3N5O7S3
• 分子量: 1265.7
• InChiKey: DSPFAKZGQWXIKD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  17.46
• 重原子数：
  87
• 可旋转键数：
  6
• 环数：
  15.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  290
• 氢给体数：
  7
• 氢受体数：
  12

文献信息

• [EN] THIENOPYRIDONE DERIVATIVES USEFUL AS ACTIVATORS OF AMPK<br/>[FR] DÉRIVÉS DE THIÉNOPYRIDONE UTILES EN TANT QU'ACTIVATEURS DE LA PROTÉINE KINASE ACTIVÉE PAR L'AMP
  申请人：POXEL

  公开号：WO2014001554A1

  公开（公告）日：2014-01-03

  Activators of AMPK and therapeutic uses thereof The invention relates to compounds that are direct activators of AMPK (AMP-activated protein kinase) and their use in the treatment of disorders regulated by activation of AMPK. For instance, compounds according to the invention are useful for the treatment of diabetes, metabolic syndrome, obesity, liver disease, hepatic steatosis, non alcoholic fatty liver disease (NAFLD), non alcoholic steato- hepatitis (NASH), liver fibrosis, dyslipidemia, hypertriglyceridemia, hypercholesterolemia, inflammation, cancer, cardiovascular diseases, atherosclerosis, high blood pressure, retinopathies or neuropathies.

  AMPK的激活剂及其治疗用途。本发明涉及直接激活AMPK（AMP-活化蛋白激酶）的化合物及其在治疗由AMPK激活调节的疾病中的应用。例如，根据本发明的化合物对于糖尿病、代谢综合征、肥胖、肝病、肝脂肪变性、非酒精性脂肪肝病（NAFLD）、非酒精性脂肪肝炎（NASH）、肝纤维化、血脂异常、高三酰甘油血症、高胆固醇血症、炎症、癌症、心血管疾病、动脉粥样硬化、高血压、视网膜病变或神经病变的治疗是有益的。
• THIENOPYRIDONE DERIVATIVES USEFUL AS ACTIVATORS OF AMPK
  申请人：Poxel

  公开号：EP2867240A1

  公开（公告）日：2015-05-06