2-[4-[4-Methyl-5-[4-(trifluoromethyl)phenyl]-1,2-oxazol-3-yl]phenoxy]-2-piperidin-1-ylacetaldehyde

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[4-[4-Methyl-5-[4-(trifluoromethyl)phenyl]-1,2-oxazol-3-yl]phenoxy]-2-piperidin-1-ylacetaldehyde
• 英文别名: 2-[4-[4-methyl-5-[4-(trifluoromethyl)phenyl]-1,2-oxazol-3-yl]phenoxy]-2-piperidin-1-ylacetaldehyde
• 化学式: C₂₄H₂₃F₃N₂O₃
• 分子量: 444.4
• InChiKey: UUMOMLSQFZDUOV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  32
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  55.6
• 氢给体数：
  0
• 氢受体数：
  8

文献信息

• [EN] NOVEL COMPOUNDS FOR THE TREATMENT OF DYSLIPIDEMIA AND RELATED DISEASES<br/>[FR] NOUVEAUX COMPOSÉS POUR LE TRAITEMENT DE LA DYSLIPIDÉMIE ET DE MALADIES ASSOCIÉES
  申请人：CADILA HEALTHCARE LTD

  公开号：WO2014002106A1

  公开（公告）日：2014-01-03

  The present invention relates to compounds of the general formula (I), their tautomeric forms, their stereoisomers, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, methods for their preparation, use of these compounds in medicine and the intermediates involved in their preparation. The present invention is directed to compounds suitable for the treatment of Disease conditions such as hyperlipidemia. The compounds of the present invention also lower LDL-c.

  本发明涉及一般式（I）的化合物，它们的互变异构体，立体异构体，药学上可接受的盐，含有它们的药物组合物，它们的制备方法，这些化合物在医学中的应用以及其制备中涉及的中间体。本发明涉及适用于治疗高脂血症等疾病状况的化合物。本发明的化合物还能降低LDL-c。