2,2-dimethylpropanoyloxymethyl (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;ethanol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: 2,2-dimethylpropanoyloxymethyl (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;ethanol
• 化学式: C22H31N5O8S2
• 分子量: 557.6
• InChiKey: GPXQHZNXTJBAKI-IZXJIOGHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.84
• 重原子数：
  37
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  236
• 氢给体数：
  3
• 氢受体数：
  13

文献信息

• METHODS FOR TREATING CANCER WITH A STAT3 PATHWAY INHIBITOR AND KINASE INHIBITOR
  申请人：Boston Biomedical, Inc.

  公开号：EP3288552A1

  公开（公告）日：2018-03-07
• [EN] SORAFENIB DERIVATIVES AS p21 INHIBITORS<br/>[FR] DÉRIVÉS DU SORAFÉNIB COMME INHIBITEURS DU P21
  申请人：UNIV CALIFORNIA

  公开号：WO2014007998A1

  公开（公告）日：2014-01-09

  The present invention provides sorafenib analogs for use in a method of treating a disease mediated by p21, said method comprising administering to a subject in need thereof a therapeutically effective amount of a compound of formula I. The present invention also provides methods of inhibiting p21 in a cell comprising contacting the cell with an effective amount of a compound of formula I.
• [EN] METHODS FOR TREATING CANCER WITH A STAT3 PATHWAY INHIBITOR AND KINASE INHIBITOR<br/>[FR] MÉTHODES DE TRAITEMENT DU CANCER À L'AIDE D'UN INHIBITEUR DE LA VOIE STAT3 ET D'UN INHIBITEUR DE KINASES
  申请人：BOSTON BIOMEDICAL INC

  公开号：WO2016176190A1

  公开（公告）日：2016-11-03

  Methods comprising administering and kits comprising at least one compound of formula A: (A) prodrugs, derivatives, pharmaceutically acceptable salts of any of the foregoing, and solvates of any of the foregoing, and at least one compound of formula B: (B) prodrugs,derivatives, pharmaceutically acceptable salts of any of the foregoing, and solvates of any of the foregoing.