1,1'-Biphenyl;1,2,3,4,5-pentachloro-6-phosphorosooxybenzene

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,1'-Biphenyl;1,2,3,4,5-pentachloro-6-phosphorosooxybenzene
• 英文别名: 1,1'-biphenyl;1,2,3,4,5-pentachloro-6-phosphorosooxybenzene
• 化学式: C18H10Cl5O2P
• 分子量: 466.5
• InChiKey: HUBVBGJHXUQGLL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.89
• 重原子数：
  26
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] PROCESS FOR PREPARING DIASTEREOMERICALLY ENRICHED PHOSPHORAMIDATE DERIVATIVES OF NUCLEOSIDE COMPOUNDS FOR TREATMENT OF VIRAL INFECTIONS<br/>[FR] PROCÉDÉ DE PRÉPARATION DE DÉRIVÉS DE PHOSPHORAMIDATES ENRICHIS EN DIASTÉRÉO-ISOMÈRES DE COMPOSÉS DE NUCLÉOSIDES, DESTINÉS AU TRAITEMENT D'INFECTIONS VIRALES
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2014008236A1

  公开（公告）日：2014-01-09

  The present invention is directed to a process for preparing diastereomerically enriched nucleoside phosphoramidates having the formula I:

  本发明涉及一种制备具有化学式I的对映异构体富集的核苷磷酰胺酯的方法。
• PROCESS FOR PREPARING DIASTEREOMERICALLY ENRICHED PHOSPHORAMIDATE DERIVATIVES OF NUCLEOSIDE COMPOUNDS FOR TREATMENT OF VIRAL INFECTIONS
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US20150183818A1

  公开（公告）日：2015-07-02

  The present invention is directed to a process for preparing diastereomerically enriched nucleoside phosphoramidates having the formula I:

  本发明涉及一种制备式I的对映体富集核苷酸磷酰胺酯的方法：
• METHODS OF PRODUCING SHIGA TOXIN B-SUBUNIT (STXB) MONOMERS AND OLIGOMERS, AND USES THEREOF
  申请人：Institut Curie

  公开号：EP3980057A1

  公开（公告）日：2022-04-13
• [EN] METHODS OF PRODUCING SHIGA TOXIN B-SUBUNIT (STxB) MONOMERS AND OLIGOMERS, AND USES THEREOF<br/>[FR] MÉTHODES DE PRODUCTION DE MONOMÈRES ET D'OLIGOMÈRES DE LA SOUS-UNITÉ B DE LA TOXINE DE SHIGA (STXB), ET LEURS UTILISATIONS
  申请人：INST CURIE

  公开号：WO2020245321A1

  公开（公告）日：2020-12-10

  The present invention relates to a method of producing a monomer of a Shiga toxin B-subunit (STxB) protein or of a variant thereof by peptide chemical synthesis, as well as to a method of producing a pentamer of the STxB protein or of the variant thereof. The methods described herein are particularly advantageous as they overcome major issues typically observed in peptide chemical synthesis, including solubility and purity issues.