[EN] SYNTHETIC OLIGOSACCHARIDES FOR P. AERUGINOSA VACCINE<br/>[FR] OLIGOSACCHARIDES DE SYNTHÈSE POUR VACCIN CONTRE P. AERUGINOSA
申请人:SYNGLYCO PHARMACEUTICALS INC
公开号:WO2015002954A1
公开(公告)日:2015-01-08
The present invention provides synthetic Pseudomonas aeruginosa lipooligosaccharide (LOS)-based oligosaccharides and conjugates containing various P. aeruginosa serotype-specific oligosaccharide antigens or various core P. aeruginosa oligosaccharide structures or motifs. The invention further provides P. aeruginosa LOS-based immunogenic and immunoprotective compositions and antibodies derived therefrom for diagnosing, treating, and preventing infections caused by P. aeruginosa.
本发明提供了合成的假单胞菌脂寡糖(LOS)基寡糖和含有不同假单胞菌血清型特异性寡糖抗原或不同核心假单胞菌寡糖结构或基序的共轭物。该发明还提供了基于假单胞菌LOS的免疫原和免疫保护组合物,以及由此衍生的抗体,用于诊断、治疗和预防由假单胞菌引起的感染。