The present invention provides synthetic Pseudomonas aeruginosa lipooligosaccharide (LOS)-based oligosaccharides and conjugates containing various P. aeruginosa serotype-specific oligosaccharide antigens or various core P. aeruginosa oligosaccharide structures or motifs. The invention further provides P. aeruginosa LOS-based immunogenic and immunoprotective compositions and antibodies derived therefrom for diagnosing, treating, and preventing infections caused by P. aeruginosa.
本发明提供了合成的假单胞菌脂
寡糖(LOS)基
寡糖和含有不同假单胞菌血清型特异性
寡糖抗原或不同核心假单胞菌
寡糖结构或基序的共轭物。该发明还提供了基于假单胞菌LOS的免疫原和免疫保护组合物,以及由此衍生的
抗体,用于诊断、治疗和预防由假单胞菌引起的感染。