2-[(3R)-1-(dimethylamino)-2-methylpentan-3-yl]phenol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[(3R)-1-(dimethylamino)-2-methylpentan-3-yl]phenol
• 化学式: C₁₄H₂₃NO
• 分子量: 221.34
• InChiKey: XBSDYTOGLDNTRZ-PIJUOVFKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Pharmaceutical device for electric-field assisted administration of Tapentadol and method of administering Tapentadol with same
  申请人：Gruenenthal GmbH

  公开号：US10632195B2

  公开（公告）日：2020-04-28

  A pharmaceutical device for electric-field assisted administration of Tapentadol and/or of a physiologically acceptable salt thereof, the device comprising at least one pair of electrodes consisting of an active electrode and a counter electrode (1a and 2a and/or 1b and 2b), optionally at least one additional electrode as an auxiliary electrode, at least one drug reservoir (3) containing at least a portion of the Tapentadol and/or a physiologically acceptable salt thereof, and means (4) for applying the device to skin (5).

  一种用于电场辅助给药他喷他多和/或其生理学上可接受的盐的制药装置，该装置包括至少一对由活性电极和对电极组成的电极（1a 和 2a 和/或 1b 和 2b），可选择至少一个额外的电极作为辅助电极，至少一个药物贮存器（3），其中至少含有一部分他喷他多和/或其生理学上可接受的盐，以及将该装置应用于皮肤（5）的装置（4）。
• ELECTRIC-FIELD ASSISTED ADMINISTRATION OF TAPENTADOL
  申请人：Grünenthal GmbH

  公开号：EP2874693A1

  公开（公告）日：2015-05-27
• Electric-Field Assisted Administration of Tapentadol
  申请人：Gruenenthal GmbH

  公开号：US20150148735A1

  公开（公告）日：2015-05-28

  A pharmaceutical device for electric-field assisted administration of Tapentadol and/or of a physiologically acceptable salt thereof, the device comprising at least one pair of electrodes consisting of an active electrode and a counter electrode ( 1 a and 2 a and/or 1 b and 2 b ), optionally at least one additional electrode as an auxiliary electrode, at least one drug reservoir ( 3 ) containing at least a portion of the Tapentadol and/or a physiologically acceptable salt thereof, and means ( 4 ) for applying the device to skin ( 5 ).
• [EN] ELECTRIC-FIELD ASSISTED ADMINISTRATION OF TAPENTADOL<br/>[FR] ADMINISTRATION ASSISTÉE PAR CHAMP ÉLECTRIQUE DE TAPENTADOL
  申请人：GRUENENTHAL GMBH

  公开号：WO2014012652A1

  公开（公告）日：2014-01-23

  A pharmaceutical device for electric-field assisted administration of Tapentadol and/or of a physiologically acceptable salt thereof, the device comprising at least one pair of electrodes consisting of an active electrode and a counter electrode (1a and 2a and/or 1 b and 2b), optionally at least one additional electrode as an auxiliary electrode, at least one drug reservoir (3) containing at least a portion of the Tapentadol and/or a physiologically acceptable salt thereof, and means (4) for applying the device to skin (5).