2-(4-chloro-N-methylsulfonylanilino)-7-oxo-4-[(2-phenylphenyl)methyl]-[1,3]thiazolo[5,4-b]pyridine-6-carboxylic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(4-chloro-N-methylsulfonylanilino)-7-oxo-4-[(2-phenylphenyl)methyl]-[1,3]thiazolo[5,4-b]pyridine-6-carboxylic acid
• 化学式: C₂₇H₂₀ClN₃O₅S₂
• 分子量: 566.0
• InChiKey: XXTFIMWPUGSQTK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  38
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  145
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• 7-OXO-4,7 -DIHYDRO- PYRAZOLO [1, 5 -A]PYRIMIDINE DERIVATIVES WHICH ARE USEFUL IN THE TREATMENT, AMELIORATION OR PREVENTION OF A VIRAL DISEASE
  申请人：Savira Pharmaceuticals GmbH

  公开号：EP2861232A1

  公开（公告）日：2015-04-22
• [EN] 7-OXO-4,7 -DIHYDRO- PYRAZOLO [1, 5 -A] PYRIMIDINE DERIVATIVES WHICH ARE USEFUL IN THE TREATMENT, AMELIORATION OR PREVENTION OF A VIRAL DISEASE<br/>[FR] DÉRIVÉS DE 7-OXO-4,7-DIHYDROPYRAZOLO[1,5-A]PYRIMIDINE QUI SONT UTILES DANS LE TRAITEMENT, L'AMÉLIORATION OU LA PRÉVENTION D'UNE MALADIE VIRALE
  申请人：SAVIRA PHARMACEUTICALS GMBH

  公开号：WO2013174931A1

  公开（公告）日：2013-11-28

  The present invention relates to a compound having the general formula (C), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, codrug, cocrystal, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, which are useful in treating, ameloriating or preventing a viral disease. Furthermore, specific combination therapies are disclosed.