5-cyclopropyl-2-fluoro-N-methylsulfonyl-4-[(3,5,7-trifluoro-1-adamantyl)methoxy]benzamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-cyclopropyl-2-fluoro-N-methylsulfonyl-4-[(3,5,7-trifluoro-1-adamantyl)methoxy]benzamide
• 化学式: C₂₂H₂₅F₄NO₄S
• 分子量: 475.5
• InChiKey: BGZNJEGXERCGGC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  32
• 可旋转键数：
  6
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  80.8
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• N-SUBSTITUTED BENZAMIDES AND THEIR USE IN THE TREATMENT OF PAIN
  申请人：Genentech, Inc.

  公开号：EP2855428A1

  公开（公告）日：2015-04-08
• N-SUBSTITUTED BENZAMIDES AND METHODS OF USE THEREOF
  申请人：GENENTECH, INC.

  公开号：US20170002017A1

  公开（公告）日：2017-01-05

  The invention provides novel compounds having the general formula: and pharmaceutically acceptable salts thereof, wherein the variables R A , subscript n, ring A, X 2 , L, subscript m, X 1 , B, R 1 , R 2 , R 3 , R 4 , R 5 and R N have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
• US8952169B2
  申请人：——

  公开号：US8952169B2

  公开（公告）日：2015-02-10
• [EN] N-SUBSTITUTED BENZAMIDES AND THEIR USE IN THE TREATMENT OF PAIN<br/>[FR] BENZAMIDES N-SUBSTITUÉS ET LEUR UTILISATION DANS LE TRAITEMENT DE LA DOULEUR
  申请人：GENENTECH INC

  公开号：WO2013177224A1

  公开（公告）日：2013-11-28

  The invention provides novel compounds having the general formula (I) and pharmaceutically acceptable salts thereof, wherein the variables RA, subscript n, ring A, X2, L, subscript m, X1, B, R1, R2, R3, R4, R5 and RN have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.