3-Cyclohexyl-1-(4-cyclohexylbutyl)-1-[2-(3-methylphenyl)ethyl]urea

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-Cyclohexyl-1-(4-cyclohexylbutyl)-1-[2-(3-methylphenyl)ethyl]urea
• 英文别名: 3-cyclohexyl-1-(4-cyclohexylbutyl)-1-[2-(3-methylphenyl)ethyl]urea
• 化学式: C₂₆H₄₂N₂O
• 分子量: 398.6
• InChiKey: SJUWBSOQGXMIDI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.7
• 重原子数：
  29
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  32.3
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• [EN] SOLUBLE COMPOUNDS FOR IMPROVED GENE THERAPY METHODS<br/>[FR] COMPOSÉS SOLUBLES POUR MÉTHODES AMÉLIORÉES DE THÉRAPIE GÉNIQUE
  申请人：BLUEBIRD BIO INC

  公开号：WO2014015318A1

  公开（公告）日：2014-01-23

  The present disclosure provides methods and compositions for improving the efficiency of cell therapy and gene delivery to cells employing compounds that modulate the peroxisome proliferator activated receptor (PP AR) signaling pathway. More particularly, methods and materials for useful for safely and reliably improving the efficiency of methods for homing or engraftment of cells, such as human hernatopoietic.stem cells (HSC), and for improving the efficiency of transducing such cells with viruses and/or viral vectors are provided. The compositions and methods are useful for therapeutic indications amenable to treatment with cell therapies and gene therapies.