5-fluoro-4-N-[(5-fluoro-2-methylsulfonylphenyl)methyl]-2-N-(1-methylpyrazol-4-yl)pyrimidine-2,4-diamine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-fluoro-4-N-[(5-fluoro-2-methylsulfonylphenyl)methyl]-2-N-(1-methylpyrazol-4-yl)pyrimidine-2,4-diamine
• 化学式: C₁₆H₁₆F₂N₆O₂S
• 分子量: 394.4
• InChiKey: WGGBGJZUGJGYQZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  110
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• [EN] HETEROCYCLYL PYRIMIDINE ANALOGUES AS TYK2 INHIBITORS<br/>[FR] ANALOGUES HÉTÉROCYCLYLE DE PYRIMIDINE COMME INHIBITEURS DE TYK2
  申请人：CELLZOME LTD

  公开号：WO2013174895A1

  公开（公告）日：2013-11-28

  The present invention relates to compounds of formula (I), wherein R, R1, X1 to X5 have the meaning as cited in the description and the claims. Said compounds are useful as TYK2 inhibitors for the treatment or prophylaxis of immunological, inflammatory, autoimmune, allergic disorders, and immunologically-mediated diseases. The invention also relates to pharmaceutical compositions including said compounds as well as their use as medicaments.

  本发明涉及式(I)的化合物，其中R、R1、X1至X5的含义如描述和权利要求中所述。所述化合物可用作TYK2抑制剂，用于治疗或预防免疫性、炎症性、自身免疫、过敏性疾病和免疫介导疾病。该发明还涉及包括所述化合物的药物组合物以及它们作为药物的用途。
• Heterocyclyl Pyrimidine Analogues As TYK2 Inhibitors
  申请人：Cellzome Limited

  公开号：US20150166513A1

  公开（公告）日：2015-06-18

  The present invention relates to compounds of formula (I) wherein R, R 1 , X 1 to X 5 have the meaning as cited in the description and the claims. Said compounds are useful as TYK2 inhibitors for the treatment or prophylaxis of immunological, inflammatory, autoimmune, allergic disorders, and immunologically-mediated diseases. The invention also relates to pharmaceutical compositions including said compounds as well as their use as medicaments.

  本发明涉及式（I）化合物，其中R、R1、X1至X5的含义如说明书和权利要求中所述。所述化合物作为TYK2抑制剂对治疗或预防免疫、炎症、自身免疫、过敏性疾病和免疫介导疾病有用。本发明还涉及包括所述化合物的制药组合物以及它们作为药物的使用。
• HETEROCYCLYL PYRIMIDINE ANALOGUES AS TYK2 INHIBITORS
  申请人：Cellzome Limited

  公开号：EP2855451A1

  公开（公告）日：2015-04-08
• US9296725B2
  申请人：——

  公开号：US9296725B2

  公开（公告）日：2016-03-29
• US9655897B2
  申请人：——

  公开号：US9655897B2

  公开（公告）日：2017-05-23