(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-ethoxy-3-[[3-(N'-hydroxycarbamimidoyl)-4-phenylphenyl]methyl]benzimidazole-4-carboxylate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-ethoxy-3-[[3-(N'-hydroxycarbamimidoyl)-4-phenylphenyl]methyl]benzimidazole-4-carboxylate
• 化学式: C₂₉H₂₆N₄O₇
• 分子量: 542.5
• InChiKey: YMKCLKQCZSSANN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  40
• 可旋转键数：
  10
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  148
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• [EN] PROCESS FOR THE PREPARATION OF (5-METHYL-2-OXO-L,3-DIOXOI-4-VL)METHVL 2- ETHOXV-L-{[2'-(5-OXO-4,5-DIHVDRO-L,2,4-OXADIAZOL-3-VL)BIPHENYI-4-VL]METHYL}- LH-BENZIMIDAZOLE-7-CARBOXYIATE AND ITS SALTS<br/>[FR] PROCÉDÉ DE PRÉPARATION DE 2-ÉTHOXY-1-{[2'-(5-OXO-4,5-DIHYDRO-1,2,4- OXADIAZOL-3-YL)BIPHÉNYL-4-YL]MÉTHYL}-LH-BENZIMIDAZOLE-7-CARBOXYLATE DE (5-MÉTHYL-2-OXO-L,3-DIOXOL-4-YL)MÉTHYLE ET DE SES SELS
  申请人：MSN LAB LTD

  公开号：WO2013186792A2

  公开（公告）日：2013-12-19

  The present invention relates to processes for the preparation of (5-methyl-2-oxo- l,3- dioxol-4-yl)methyl 2-ethoxy- 1 - [2'-(5-oxo-4,5-dihydro- 1,2,4-oxadiazol-3-yl)biphenyl-4- yl]methyl}-lH-benzimidazole-7-carboxylate compound of formula- 1, its potassium salt compound of formula- la and polymorphs thereof.