2-Methyl-2-(3-phenoxyphenyl)butanoic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Methyl-2-(3-phenoxyphenyl)butanoic acid
• 英文别名: 2-methyl-2-(3-phenoxyphenyl)butanoic acid
• 化学式: C₁₇H₁₈O₃
• 分子量: 270.32
• InChiKey: PEYFRPYHHGYOMC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• COMPOSITIONS AND METHODS FOR SUBSTRATE-SELECTIVE INHIBITION OF ENDOCANNABINOID OXYGENATION
  申请人：Vanderbilt University

  公开号：US20150183737A1

  公开（公告）日：2015-07-02

  Methods for selectively inhibiting endocannabinoid oxygenation but not arachidonic acid oxygenation. In some embodiments, the methods include contacting a COX-2 polypeptide with an effective amount of a substrate-selective COX-2 inhibitor. Also provided are methods for elevating a local endogenous cannabinoid concentrations; methods of reducing depletion of an endogenous cannabinoid; methods for inducing analgesia; methods of providing anxiolytic therapy; methods for providing anti-depressant therapy; and compositions for performing the disclosed methods.
• [EN] COMPOSITIONS AND METHODS FOR SUBSTRATE-SELECTIVE INHIBITION OF ENDOCANNABINOID OXYGENATION<br/>[FR] COMPOSITIONS ET PROCÉDÉS POUR UNE INHIBITION SÉLECTIVE DU SUBSTRAT DE L'OXYGÉNATION DES ENDOCANNABINOÏDES
  申请人：UNIV VANDERBILT

  公开号：WO2014015341A2

  公开（公告）日：2014-01-23

  Methods for selectively inhibiting endocannabinoid oxygenation but not arachidonic acid oxygenation. In some embodiments, the methods include contacting a COX-2 polypeptide with an effective amount of a substrate-selective COX-2 inhibitor. Also provided are methods for elevating a local endogenous cannabinoid concentrations; methods of reducing depletion of an endogenous cannabinoid; methods for inducing analgesia; methods of providing anxiolytic therapy; methods for providing anti-depressant therapy; and compositions for performing the disclosed methods.