tert-butyl (3aR,6aS)-6a-(2-fluorophenyl)-3,3a,4,6-tetrahydro-1H-pyrrolo[3,4-c][1,2]oxazole-5-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: tert-butyl (3aR,6aS)-6a-(2-fluorophenyl)-3,3a,4,6-tetrahydro-1H-pyrrolo[3,4-c][1,2]oxazole-5-carboxylate
• 化学式: C₁₆H₂₁FN₂O₃
• 分子量: 308.35
• InChiKey: PJSFHEHJLDASJH-ZBEGNZNMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  50.8
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] HEXAHYDROPYRROLOTHIAZINE COMPOUNDS<br/>[FR] COMPOSÉS D'HEXAHYDROPYRROLOTHIAZINE
  申请人：EISAI R&D MAN CO LTD

  公开号：WO2014013076A1

  公开（公告）日：2014-01-23

  A compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 to R9 are as defined in the specification and which compound has an Αβ production inhibitory effect and may be useful as a prophylactic or therapeutic agent for a neurodegenerative disease caused by Αβ and typified by Alzheimer-type dementia (AD) or Down's syndrome.

  公式（I）的化合物或其药用盐，其中R1至R9如规范中定义，并且该化合物具有抑制Αβ产生的效果，可能作为一种预防或治疗剂用于由Αβ引起的以阿尔茨海默症（AD）或唐氏综合征为特征的神经退行性疾病。
• COMPOSITIIONS COMPRISING A BIOLOGICAL CONTROL AGENT AND AN INSECTICIDE
  申请人：Bayer CropScience AG

  公开号：EP2854534A1

  公开（公告）日：2015-04-08
• [EN] COMPOSITIIONS COMPRISING A BIOLOGICAL CONTROL AGENT AND AN INSECTICIDE<br/>[FR] COMPOSITIONS COMPRENANT UN AGENT DE LUTTE BIOLOGIQUE ET UN INSECTICIDE
  申请人：BAYER CROPSCIENCE AG

  公开号：WO2013178661A1

  公开（公告）日：2013-12-05

  The present Invention relates to a composition comprising at least one biological control agent selected from the group consisting of Bacillus chitinosporus AQ746 (NRRL Accession No, B-21 61 8), Bacillus mycoides AQ726 (NRRL Accession No, B- 21664), Bacillus pumilus (NRRL Accession No, B-30087), Bacillus pumilus AQ717 (NRRL Accession No. B-21662), Bacillus sp. AQ1 75 (ATCC Accession No. 55608), Bacillus sp. AQ177 (ATCC Accession No. 55609), Bacillus sp. AQ178 (ATCC Accession No, 53522), Bacillus subtilis AQ743 (NRRL Accession No. B-21665), Bacillus subtilis AQ713 (NRRL Accession No. B- 21661), Bacillus subtilis AQ153 (ATCC Accession No. 55614), Bacillus thuringiensis BD#32 (NRRL Accession No. B-21530), Bacillus thuringiensis AQ52 (NRRL Accession No, B- 21619), Muscodor albus 620 (NRRL Accession No. 30547), Muscodor roseus A3-5 (NRRL Accession No, 30548), Rhodococcus globerulus AQ719 (NRRL Accession No, B- 21663), Streptomyces galbus (NRRL Accession No, 30232), Steptomyces sp. (NRRL Accession No. B-30145), Bacillus thuringiensis subspec. kurstaki BMP 123, Bacillus subtilis AQ30002 (NRRL Accession No. B-50421), and Bacillus subtilis AG 30004 (NRRL Accession No. B-50455) and/or a mutant of these strains having all the identifying characteristics of the respective strain, and/or a metabolite produced by the respective strain that exhibits activity against insects, mites, nematodes and/or phytoparthogens and at least one insecticide selected from the group consisting of nicotinic acetylcholine receptor (nAChR) agonists and nicotinic acetylcholine receptor (nAChR) allosteric activators in a synergistically effective amount. Furthermore, the present invention relates to the use of this composition as well as a method for reducing overall damage of plants and plant parts.