1-iodo-2H-pyridine-5-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1-iodo-2H-pyridine-5-carboxylic acid
• 化学式: C₆H₆INO₂
• 分子量: 251.02
• InChiKey: KMURHXGTIBYDBF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Targeting cancer cells and tissue using filamentous plant virus particles
  申请人：CASE WESTERN RESERVE UNIVERSITY

  公开号：US10232057B2

  公开（公告）日：2019-03-19

  A filamentous plant virus carrier comprising a filamentous plant virus particle that has been modified to carry an imaging agent or cytotoxic compound is described. The filamentous plant virus carrier can be used in a method of targeting cancer cells and tissue by administering it to a subject. Cancer tissue targeted by the filamentous plant virus carrier can be imaged using an imaging agent, or treated using a cytotoxic compound.

  本文描述了一种丝状植物病毒载体，它由丝状植物病毒颗粒组成，该病毒颗粒经过修饰，可携带成像剂或细胞毒性化合物。丝状植物病毒载体可用于靶向癌细胞和组织的方法中，将其施用到受试者身上。丝状植物病毒载体靶向的癌组织可使用成像剂成像，或使用细胞毒性化合物治疗。
• Anticancer drug-containing plant virus particles
  申请人：CASE WESTERN RESERVE UNIVERISTY

  公开号：US10624975B2

  公开（公告）日：2020-04-21

  Anticancer virus particles are described. Anticancer virus particles are filamentous or rod-shaped plant virus particle containing an anticancer agent within the interior of the virus particle. The anticancer agent can be attached either covalently or non-covalently within the interior of the virus particle. A therapeutically effective amount of an anticancer virus particle can be administered to a subject identified as having cancer to provide a method of cancer treatment.

  描述了抗癌病毒颗粒。抗癌病毒颗粒是丝状或杆状植物病毒颗粒，病毒颗粒内部含有抗癌剂。抗癌剂可以共价或非共价方式附着在病毒颗粒内部。可将治疗有效量的抗癌病毒颗粒施用给确定患有癌症的受试者，以提供一种癌症治疗方法。
• ANTICANCER DRUG-CONTAINING PLANT VIRUS PARTICLES
  申请人：Case Western Reserve University

  公开号：EP3313527A1

  公开（公告）日：2018-05-02
• TARGETING CANCER CELLS AND TISSUE USING FILAMENTOUS PLANT VIRUS PARTICLES
  申请人：CASE WESTERN RESERVE UNIVERSITY

  公开号：US20170106098A1

  公开（公告）日：2017-04-20

  A filamentous plant virus carrier comprising a filamentous plant virus particle that has been modified to carry an imaging agent or cytotoxic compound is described. The filamentous plant virus carrier can be used in a method of targeting cancer cells and tissue by administering it to a subject. Cancer tissue targeted by the filamentous plant virus carrier can be imaged using an imaging agent, or treated using a cytotoxic compound.
• ANTICANCER TRAIL-TARGETED PLANT VIRUS PARTICLES
  申请人：CASE WESTERN RESERVE UNIVERSITY

  公开号：US20200179468A1

  公开（公告）日：2020-06-11

  An agent is described that includes a plant virus particle or VLP conjugate to TRAIL. Associating TRAIL with the plant virus particle or VLP serves to both target cancer cells and induce their apoptosis. The agent can therefore be used for a method of treating cancer in a subject.