3H-pyrrolo[1,2-a]imidazole-3-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 杂芳族化合物
• 英文名称: 3H-pyrrolo[1,2-a]imidazole-3-carboxamide
• 化学式: C₇H₇N₃O
• 分子量: 149.15
• InChiKey: BRZMPKDWTNMPDB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  60.4
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• 5,5-HETEROAROMATIC ANTI-INFECTIVE COMPOUNDS
  申请人：UNIVERSITY OF NOTRE DAME DU LAC

  公开号：US20150210715A1

  公开（公告）日：2015-07-30

  The invention provides a series of 5,5-heteroaromatic compounds, syntheses thereof, compositions thereof, and methods of using such compounds and compositions. Various embodiments provide methods of killing and/or inhibiting the growth of M. tuberculosis and/or M. avium , and methods of treating, preventing, and/or ameliorating M. tuberculosis and/or M. avium infections in a subject. In various embodiments, the 5,5-heteroaromatic compound is N-(4-(4-chlorophenoxy)benzyl)-2,6-dimethylimidazo[2,1-b]thiazole-5-carboxamide.

  该发明提供了一系列5,5-杂环芳烃化合物，其合成方法，组合物以及使用这些化合物和组合物的方法。各种实施方式提供了杀灭和/或抑制结核分枝杆菌和/或分枝杆菌的生长的方法，以及治疗、预防和/或改善受试者体内结核分枝杆菌和/或分枝杆菌感染的方法。在各种实施方式中，5,5-杂环芳烃化合物为N-(4-(4-氯苯氧基)苄基)-2,6-二甲基咪唑[2,1-b]噻唑-5-羧酰胺。
• US9605002B2
  申请人：——

  公开号：US9605002B2

  公开（公告）日：2017-03-28
• [EN] 5,5-HETEROAROMATIC ANTI-INFECTIVE COMPOUNDS<br/>[FR] COMPOSÉS ANTI-INFECTIEUX 5,5-HÉTÉROAROMATIQUES
  申请人：MORASKI GARRETT

  公开号：WO2014015167A2

  公开（公告）日：2014-01-23

  The invention provides a series of 5,5-heteroaromatic compounds, syntheses thereof, compositions thereof, and methods of using such compounds and compositions. Various embodiments provide methods of killing and/or inhibiting the growth of M. tuberculosis and/or M. avium, and methods of treating, preventing, and/or ameliorating M. tuberculosis and/or M. avium infections in a subject. In various embodiments, the 5,5-heteroaromatic compound is N-(4-(4-chlorophenoxy)benzyl)-2,6-dimethylimidazo[2,1-b]thiazole-5-carboxamide.