tert-butyl 2-[4-[6-amino-5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-3-yl]pyrazol-1-yl]piperidine-1-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: tert-butyl 2-[4-[6-amino-5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-3-yl]pyrazol-1-yl]piperidine-1-carboxylate
• 化学式: C₂₆H₃₀Cl₂FN₅O₃
• 分子量: 550.4
• InChiKey: QBAMOHNHIUVMOF-RBFZIWAESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  37
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  95.5
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• [EN] PROCESS FOR THE PREPARATION OF PYRAZOLE SUBSTITUTED AMINOHETEROARYL COMPOUNDS<br/>[FR] PROCÉDÉ DE PRÉPARATION DE COMPOSÉS D'AMINOHÉTÉROARYLE À SUBSTITUTION PYRAZOLE
  申请人：FRESENIUS KABI ONCOLOGY LTD

  公开号：WO2014020467A2

  公开（公告）日：2014-02-06

  The present invention relates to an improved process for the preparation of pyrazole substituted aminoheteroaryl compounds. More particularly, the present invention provides highly pure 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-ylpyrazol-4- yl)pyridin-2-amine, its intermediates and preparation thereof. The process of the present invention is simple, convenient, does not use expensive chemicals and avoids use of tedious purification techniques. Invention also provides process intermediates, useful not only in the synthesis, but also useful for providing desired compound with high purity.