2-(2-Chlorophenyl)-2-(methylamino)cyclohexan-1-one;sulfuric acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(2-Chlorophenyl)-2-(methylamino)cyclohexan-1-one;sulfuric acid
• 英文别名: 2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one;sulfuric acid
• 化学式: C13H18ClNO5S
• 分子量: 335.8
• InChiKey: DMZWHSROFNTZCE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.25
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  112
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• MAINTENANCE THERAPY USING TIANEPTINE
  申请人：GENOMIND, Inc.

  公开号：US20180042936A1

  公开（公告）日：2018-02-15

  The present application provides a method for treating treatment-resistant depression in a patient in need thereof, comprising administering to said patient a therapeutically effective amount of tianeptine, subsequent to a ketamine treatment; also provided is a method of treating suicidal ideation (SI), post-traumatic stress disorder (PTSD), mild cognitive impairment (MCI) or pre-dementia co-morbid with symptoms of depression; and further provided is maintenance therapy for depression remission.
• [EN] ORAL TRANSMUCOSAL ADMINSTRATION FORMS OF S-KETAMINE<br/>[FR] FORMES D'ADMINISTRATION TRANSMUQUEUSE ORALE DE KÉTAMINE S
  申请人：CLINPHARM REFORM GMBH

  公开号：WO2014020155A1

  公开（公告）日：2014-02-06

  The present invention relates to methods and compositions for the treatment of pain, in a preferred embodiment relating to the oral transmucosal administration of S-Ketamine, its salts or derivatives.
• [EN] PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE<br/>[FR] COMPOSITIONS PHARMACEUTIQUES ET MÉTHODES D'UTILISATION
  申请人：IMPAX LABORATORIES INC

  公开号：WO2015051259A1

  公开（公告）日：2015-04-09

  Disclosed are compositions and methods for administering an NMDA receptor antagonist to a patient. The compositions may be administered orally, buccally, sublingually or rectally.