4-[4-[1-[(2-Fluorophenyl)methyl]pyrazol-4-yl]-1-(4-methylphenyl)sulfonylpyrrol-2-yl]-1-methylpyrazole

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-[4-[1-[(2-Fluorophenyl)methyl]pyrazol-4-yl]-1-(4-methylphenyl)sulfonylpyrrol-2-yl]-1-methylpyrazole
• 英文别名: 4-[4-[1-[(2-fluorophenyl)methyl]pyrazol-4-yl]-1-(4-methylphenyl)sulfonylpyrrol-2-yl]-1-methylpyrazole
• 化学式: C₂₅H₂₂FN₅O₂S
• 分子量: 475.5
• InChiKey: XNDVHPMJDCGUPQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  34
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  83.1
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• 5-(1H-PYRAZOL-4-YL)-1H-PYRROLO[2,3-b]PYRIDINE DERIVATIVES AS KINASE INHIBITORS
  申请人：Aurigene Discovery Technologies Limited

  公开号：EP2882748A1

  公开（公告）日：2015-06-17
• [EN] 5-(1H-PYRAZOL-4-YL)-1H-PYRROLO[2,3-b]PYRIDINE DERIVATIVES AS KINASE INHIBITORS<br/>[FR] DÉRIVÉS DE 5-(1H-PYRAZOL-4-YL)-1H-PYRROLO[2,3-B]PYRIDINE UTILISÉS COMME INHIBITEURS DE KINASES
  申请人：AURIGENE DISCOVERY TECH LTD

  公开号：WO2014024077A1

  公开（公告）日：2014-02-13

  The present application relates to novel 5-(1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine derivatives of formula (I), as protein kinase inhibitors. The invention particularly relates to compounds of formula (I), preparation of compounds and pharmaceutical compositions thereof. The invention further relates to prodrugs, derivatives, polymorphs, pharmaceutically acceptable salts and compositions comprising the said novel 5-(1H-pyrazol-4-yl)-1H- pyrrolo[2,3-b]pyridine compounds and their derivatives and their use in the treatment of various disorders.