(6R,7R)-3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-8-oxo-7-[[2-(tetrazol-1-yl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;silver

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: (6R,7R)-3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-8-oxo-7-[[2-(tetrazol-1-yl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;silver
• 化学式: C14H14AgN8O4S3
• 分子量: 562.4
• InChiKey: LKEDWBBCMCJSSO-WYUVZMMLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.64
• 重原子数：
  30
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  235
• 氢给体数：
  2
• 氢受体数：
  12

文献信息

• CONJUGATED ANTI-MICROBIAL COMPOUNDS AND CONJUGATED ANTI-CANCER COMPOUNDS AND USES THEREOF
  申请人：PONO CORPORATION

  公开号：US20150150995A1

  公开（公告）日：2015-06-04

  Disclosed herein are synthesis methods for generation of conjugated anti-microbial compounds and conjugated anti-cancer compounds. Several embodiments, related to the uses of such compounds in the treatment of infections, in particular those caused by drug-resistant bacteria. Some embodiments relate to targeting cancer based on the metabolic signature of tumor cells.

  本文公开了合成共轭抗微生物化合物和共轭抗癌化合物的方法。其中几种实施例与上述化合物在治疗感染方面的应用有关，特别是那些由耐药细菌引起的感染。一些实施例涉及基于肿瘤细胞代谢特征的癌症治疗。
• [EN] CONJUGATED ANTI-MICROBIAL COMPOUNDS AND CONJUGATED ANTI-CANCER COMPOUNDS AND USES THEREOF<br/>[FR] COMPOSÉS ANTIMICROBIENS CONJUGUÉS ET COMPOSÉS ANTICANCÉREUX CONJUGUÉS ET LEURS UTILISATIONS
  申请人：PONO CORP

  公开号：WO2014026143A1

  公开（公告）日：2014-02-13

  Disclosed herein are synthesis methods for generation of conjugated anti-microbial compounds and conjugated anti-cancer compounds. Several embodiments, related to the uses of such compounds in the treatment of infections, in particular those caused by drug-resistant bacteria. Some embodiments relate to targeting cancer based on the metabolic signature of tumor cells.