N-cyclopropyl-3-[4-(4-fluorophenyl)sulfonylpiperidin-1-yl]-7-methylpyrido[3,4-b]pyrazin-2-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶吡嗪类
• 英文名称: N-cyclopropyl-3-[4-(4-fluorophenyl)sulfonylpiperidin-1-yl]-7-methylpyrido[3,4-b]pyrazin-2-amine
• 化学式: C₂₂H₂₄FN₅O₂S
• 分子量: 441.5
• InChiKey: DDIFBPZWYSSKKC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  31
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  96.5
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• QUINOXALINE DERIVATIVES AS GPR6 MODULATORS
  申请人：ENVOY THERAPEUTICS, INC.

  公开号：US20150232469A1

  公开（公告）日：2015-08-20

  The present invention provides compounds of Formula (I): that are GPR6 modulators and are therefore useful for the treatment of diseases treatable by modulation of GPR6, in particular treating Parkinson disease, levodopa induced dyskinesias, Huntington's disease, other dyskinesias, akinesias, and motor disorders involving dysfunction of the striatum, schizophrenia and drug addiction. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.

  本发明提供的化合物为式(I)的GPR6调节剂，因此可用于治疗可通过GPR6调节治疗的疾病，特别是治疗帕金森病、左多巴引起的运动障碍、亨廷顿病、其他运动障碍、无动力障碍以及涉及纹状体功能障碍的运动障碍、精神分裂症和药物成瘾。还提供了含有这种化合物的制药组合物以及制备这种化合物的过程。
• Tetrahydropyridopyrazines as modulators of GPR6
  申请人：Takeda Pharmaceutical Company Limited

  公开号：US10179783B2

  公开（公告）日：2019-01-15

  The present invention provides compounds of formula I: which are useful as modulators of GPR6, pharmaceutical compositions thereof, methods for treatment of conditions associated with GPR6, processes for making the compounds and intermediates thereof.

  本发明提供了式 I 的化合物： 可用作 GPR6 的调节剂、其药物组合物、治疗与 GPR6 有关的疾病的方法、制造这些化合物的工艺及其中间体。
• TETRAHYDROPYRIDOPYRAZINES MODULATORS OF GPR6
  申请人：Hitchcock Stephen

  公开号：US20170174677A1

  公开（公告）日：2017-06-22

  The present invention provides compounds of formula I: which are useful as modulators of GPR6, pharmaceutical compositions thereof, methods for treatment of conditions associated with GPR6, processes for making the compounds and intermediates thereof.
• US9487526B2
  申请人：——

  公开号：US9487526B2

  公开（公告）日：2016-11-08