(7,8-Dimethoxy-6-methylpyrazolo[3,4-c]cinnolin-3-yl)-phenylmethanone

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (7,8-Dimethoxy-6-methylpyrazolo[3,4-c]cinnolin-3-yl)-phenylmethanone
• 英文别名: (7,8-dimethoxy-6-methylpyrazolo[3,4-c]cinnolin-3-yl)-phenylmethanone
• 化学式: C₁₉H₁₆N₄O₃
• 分子量: 348.4
• InChiKey: MIQNSQLKKZQKQB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  79.1
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• [EN] INHIBITOR COMPOUNDS OF PHOSPHODIESTERASE TYPE 10A<br/>[FR] COMPOSÉS INHIBITEURS DE LA PHOSPHODIESTÉRASE DE TYPE A10
  申请人：ABBVIE DEUTSCHLAND

  公开号：WO2014027078A1

  公开（公告）日：2014-02-20

  The present invention relates to compounds of the formula I, the N-oxides, tautomers, the prodrugs and the pharmaceutically acceptable salts thereof, where in formula I the variables R1, R2, R3, R4 and R5 are as defined in the claims and where X is C-R6 or N,Y is C-R7 or N, where R6 and R7 are, inter alia, hydrogen, halogen, alkoxy, haloalkoxy and the like. The compounds of the formula I, the N-oxides, tautomers,the prodrugs and the pharmaceutically acceptable salts thereof are inhibitors of phosphodiesterase type 10A and to their use for the manufacture of a medicament and which thus are suitable for treating or controlling of medical disorders selected from neurological disorders and psychiatric disorders, for ameliorating the symptoms associated with such disorders and for reducing the risk of such disorders.

  本发明涉及公式I的化合物，其N-氧化物，互变异构体，前药和其药学上可接受的盐，其中在公式I中，变量R1，R2，R3，R4和R5如权利要求所定义，并且其中X是C-R6或N，Y是C-R7或N，其中R6和R7是氢，卤素，烷氧基，卤代烷氧基等。公式I的化合物，其N-氧化物，互变异构体，前药和其药学上可接受的盐是磷酸二酯酶10A的抑制剂，适用于制造药物，因此适用于治疗或控制神经系统疾病和精神障碍，改善与此类疾病相关的症状并降低此类疾病的风险。
• INHIBITOR COMPOUNDS OF PHOSPHODIESTERASE TYPE 10A
  申请人：AbbVie Deutschland GmbH & Co KG

  公开号：EP2885299A1

  公开（公告）日：2015-06-24