(4Z)-2-(3-fluorophenyl)-4-[[6-hydroxy-5-phenyl-1-(2H-tetrazol-5-yl)cyclohexa-2,4-dien-1-yl]hydrazinylidene]-5-methylpyrazol-3-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (4Z)-2-(3-fluorophenyl)-4-[[6-hydroxy-5-phenyl-1-(2H-tetrazol-5-yl)cyclohexa-2,4-dien-1-yl]hydrazinylidene]-5-methylpyrazol-3-one
• 化学式: C₂₃H₁₉FN₈O₂
• 分子量: 458.4
• InChiKey: VCGCVIPFIWDJQR-PLRJNAJWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  34
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  132
• 氢给体数：
  3
• 氢受体数：
  9

文献信息

• [EN] THROMBOPOIETIN MIMETICS FOR THE TREATMENT OF RADIATION OR CHEMICAL INDUCED BONE MARROW INJURY<br/>[FR] MIMÉTIQUES DE THROMBOPOÏÉTINE POUR LE TRAITEMENT DE LÉSION DE LA MOELLE OSSEUSE INDUITE PAR UN RAYONNEMENT OU UN PRODUIT CHIMIQUE
  申请人：UNIV ROCHESTER

  公开号：WO2014028509A2

  公开（公告）日：2014-02-20

  Disclosed are transgenic non-human mammals, which useful for the screening of thrombopoietin mimetics, thrombopoietin receptor agonists, or thrombopoietin receptor antagonists active on the human thrombopoietin receptor. The transgenic non-human mammal has a genome that comprises a stably integrated transgene construct comprising a polynucleotide sequence encoding a humanized thrombopoietin receptor wherein said transgenic non-human mammal has a baseline blood platelet count corresponding to a physiological blood platelet count of a matched non-transgenic non- human mammal. The chimeric thrombopoietin receptor comprises either the transmembrane domain of a human thrombopoietin receptor or both the extracellular and transmembrane domains of a human thrombopoietin receptor operably coupled to a cytoplasmic domain of a non-human thrombopoietin receptor.